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Am J Physiol Endocrinol Metab 283: E536-E544, 2002. First published May 28, 2002; doi:10.1152/ajpendo.00094.2001
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Vol. 283, Issue 3, E536-E544, September 2002

Intracranial administration of transforming growth factor-beta 3 increases fat oxidation in rats

Hanae Yamazaki, Masanao Arai, Shigenobu Matsumura, Kazuo Inoue, and Tohru Fushiki

Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan

The effects of intracranial transforming growth factor (TGF)-beta 3 on spontaneous motor activity and energy metabolism were examined in rats. After injection of TGF-beta 3 into the cisterna magna of the rat, spontaneous motor activity decreased significantly for 1 h. The intracranial injection of TGF-beta 3 produced an immediate decrease in respiratory exchange ratio (RER). No significant changes were observed in energy expenditure. TGF-beta 3 induced a significant increase in total fat oxidation and a decrease in total carbohydrate oxidation. Furthermore, the serum substrates associated with fat metabolism were significantly altered in rats injected with TGF-beta 3. Both lipoprotein lipase activity in skeletal muscle and the concentration of serum ketone bodies increased, suggesting that the increase in fat oxidation caused by TGF-beta 3 may have occurred in the liver and muscle. Intracranial injection of TGF-beta 3 appeared to evoke a switch in the energy substrates accessed in energy expenditure. These results suggest that the release of TGF-beta 3 in the brain by exercise is a signal for regulating energy consumption.

spontaneous motor activity; respiratory exchange ratio; energy metabolism


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