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Am J Physiol Endocrinol Metab 283: E428-E435, 2002; doi:10.1152/ajpendo.00019.2002
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Vol. 283, Issue 3, E428-E435, September 2002

Thyroid hormone and cardiac function in mice deficient in thyroid hormone receptor-alpha or -beta : an echocardiograph study

Roy E. Weiss1, Claudia Korcarz1, Olivier Chassande3, Kevin Cua1, Peter M. Sadow2, Eugene Koo1, Jacques Samarut3, and Roberto Lang1

Departments of 1 Medicine and 2 Pathology, University of Chicago, Chicago, Illinois 60637; and 3 Laboratoire de Biologie Moleculaire et Cellulaire de l'Ecole Normale Supérieure de Lyon, 69364 Lyon, France

We investigated the effect of thyroid hormone (TH) receptor (TR)alpha and -beta isoforms in TH action in the heart. Noninvasive echocardiographic measurements were made in mice homozygous for disruption of TRalpha (TRalpha 0/0) or TRbeta (TRbeta -/-). Mice were studied at baseline, 4 wk after TH deprivation (using a low-iodine diet containing propylthiouracil), and after 4-wk treatment with TH. Baseline heart rates (HR) were similar in wild-type (WT) and TRalpha 0/0 mice but were greater in TRbeta -/- mice. With TH deprivation, HR decreased 49% in WT and 37% in TRbeta -/- mice and decreased only 5% in TRalpha 0/0 mice from baseline, whereas HR increased in all genotypes with TH treatment. Cardiac output (CO) and cardiac index (CI) in WT mice decreased (-31 and -32%, respectively) with TH deprivation and increased (+69 and +35%, respectively) with TH treatment. The effects of CO and CI were blunted with TH withdrawal in both TRalpha 0/0 (+8 and -2%, respectively) and TRbeta -/- mice (-17 and -18%, respectively). Treatment with TH resulted in a 64% increase in LV mass in WT and a 44% increase in TRalpha 0/0 mice but only a 6% increase in TRbeta -/- mice (ANOVA P < 0.05). Taken together, these data suggest that TRalpha and TRbeta play different roles in the physiology of TH action on the heart.

left ventricular mass; thyrotropin; cardiac index; cardiac output; shortening fraction


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