| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Research Center and 2 Department of Pathology, Hôpital Sainte-Justine, and 3 Department of Obstetrics and Gynecology, Université de Montréal, Montreal, Quebec, Canada H3T 1C5
Epidemiological studies have produced evidence that unfavorable intrauterine environments during fetal life may lead to adverse outcomes in adulthood. We have previously shown that a low-sodium diet, given to pregnant rats over the last week of gestation, results in intrauterine growth restriction (IUGR). We hypothesize that pups born with IUGR are more susceptible to the development of hypertension in adulthood. IUGR fetuses and rats aged 1 wk were characterized for organ growth and renal morphogenesis. The adults (12 wk) were evaluated for weight, systolic blood pressure, activity of the renin-angiotensin-aldosterone system (RAAS), and renal function; hearts and kidneys underwent a histological examination. Brain and cardiac ventricle-to-body ratios were increased in IUGR fetuses compared with age-matched controls, whereas the kidney-to-body ratio was unchanged. Systolic blood pressure was elevated in both IUGR male and female adults. Plasma aldosterone levels were not correlated with increased plasma renin activity. Moreover, urinary sodium was decreased, whereas plasma urea was elevated in both males and females, and creatinine levels were augmented only in females, suggesting a glomerular filtration impairment in IUGR. In our model of IUGR induced by a low-sodium diet given to pregnant rats, high blood pressure, alteration of the RAAS, and renal dysfunction are observed in adult life. Differences observed between male and female adults suggest the importance of gender in outcomes in adulthood after IUGR.
fetal programming; renin-angiotensin-aldosterone system
This article has been cited by other articles:
|
|
 |
|
  J. P. Porter, S. H. King, and A. D. Honeycutt Prenatal high-salt diet in the Sprague-Dawley rat programs blood pressure and heart rate hyperresponsiveness to stress in adult female offspring Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R334 - R342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Baserga, M. A. Hale, Z. M. Wang, X. Yu, C. W. Callaway, R. A. McKnight, and R. H. Lane Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1943 - R1955. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Fagerudd, C. Forsblom, K. Pettersson-Fernholm, M. Saraheimo, J. Waden, M. Ronnback, M. Rosengard-Barlund, C.-G. a. Bjorkesten, L. Thorn, M. Wessman, et al. Low birth weight does not increase the risk of nephropathy in Finnish type 1 diabetic patients Nephrol. Dial. Transplant., August 1, 2006; 21(8): 2159 - 2165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Baserga, M. A. Hale, X. Ke, Z. M. Wang, X. Yu, C. W. Callaway, R. A. McKnight, and R. H. Lane Uteroplacental insufficiency increases p53 phosphorylation without triggering the p53-MDM2 functional circuit response in the IUGR rat kidney Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2006; 291(2): R412 - R418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Gibson, C. L. Thomson, A. C. Boyce, B. M. Karime, and E. R. Lumbers Effects of a reduction in maternal renal mass on pregnancy and cardiovascular and renal function of the pregnant ewe Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1153 - F1162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Mullins, M. A. Bailey, and J. J. Mullins Hypertension, Kidney, and Transgenics: A Fresh Perspective Physiol Rev, April 1, 2006; 86(2): 709 - 746. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Anderson, F. Lopez, A. Zimmer, and J. N. Benoit Placental Insufficiency Leads to Developmental Hypertension and Mesenteric Artery Dysfunction in Two Generations of Sprague-Dawley Rat Offspring Biol Reprod, March 1, 2006; 74(3): 538 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Keijzer-Veen, M. Schrevel, M. J.J. Finken, F. W. Dekker, J. Nauta, E. T.M. Hille, M. Frolich, B. J. van der Heijden, and on behalf of the Dutch POPS-19 Collaborative Study Microalbuminuria and Lower Glomerular Filtration Rate at Young Adult Age in Subjects Born Very Premature and after Intrauterine Growth Retardation J. Am. Soc. Nephrol., September 1, 2005; 16(9): 2762 - 2768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. Sanders, G. E. Fazzi, G. M.J. Janssen, C. E. Blanco, and J. G.R. De Mey High Sodium Intake Increases Blood Pressure and Alters Renal Function in Intrauterine Growth-Retarded Rats Hypertension, July 1, 2005; 46(1): 71 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-C. Battista, E. Calvo, A. Chorvatova, B. Comte, J. Corbeil, and M. Brochu Intra-uterine growth restriction and the programming of left ventricular remodelling in female rats J. Physiol., May 15, 2005; 565(1): 197 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A Armitage, I. Y Khan, P. D Taylor, P. W Nathanielsz, and L. Poston Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals? J. Physiol., December 1, 2004; 561(2): 355 - 377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Sanders, G. E. Fazzi, G. M.J. Janssen, P. W. de Leeuw, C. E. Blanco, and J. G.R. De Mey Reduced Uteroplacental Blood Flow Alters Renal Arterial Reactivity and Glomerular Properties in the Rat Offspring Hypertension, June 1, 2004; 43(6): 1283 - 1289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Denton, R. L. Flower, K. M. Stevenson, and W. P. Anderson Adult Rabbit Offspring of Mothers With Secondary Hypertension Have Increased Blood Pressure Hypertension, March 1, 2003; 41(3): 634 - 639. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
