AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 282: E1245-E1254, 2002. First published February 19, 2002; doi:10.1152/ajpendo.00363.2001
0193-1849/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/6/E1245    most recent
00363.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (20)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gotoh, Y.
Right arrow Articles by Sugiyama, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gotoh, Y.
Right arrow Articles by Sugiyama, Y.
Vol. 282, Issue 6, E1245-E1254, June 2002

Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17beta -D-glucuronide in rats

Yasumasa Gotoh1, Yukio Kato1,2, Bruno Stieger3, Peter J. Meier3, and Yuichi Sugiyama1,2

1 Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033; 2 Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Kawaguchi 332-0012, Japan; and 3 Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH-8901 Zurich, Switzerland

The gender difference in the urinary excretion of estradiol-17beta -glucuronide (E2-17beta G) was examined in rats. The urinary clearance of E2-17beta G was >250 times lower in male than in female rats. No such major gender difference was observed in its biliary excretion or metabolism in kidney homogenate. Both plasma protein binding and inulin clearance were comparable in male and female rats, suggesting that this gender difference cannot be explained by glomerular filtration. The urinary clearance with respect to the plasma unbound E2-17beta G in male rats was <1% of the glomerular filtration rate, indicating its potential reabsorption by the kidney, and this increased to a level comparable with that found in female rats when dibromosulfophthalein was coinfused. A marked increase in E2-17beta G urinary excretion was also observed in male rats that had undergone orchidectomy. Testosterone injections given to female rats reduced the urinary excretion to a level comparable with that of control male rats. The concomitant change in the expression of the gene product for organic anion-transporting polypeptide Oatp1, of which E2-17beta G is a typical substrate, was found in the kidney membrane fractions after these treatments. These results suggest that urinary E2-17beta G excretion is subject to hormonal regulation and that the large gender difference can be explained by regulation in Oatp1-mediated reabsorption.

gender difference; urinary excretion; reabsorption; organic anion-transporting polypeptide 1; multispecific resistance-associated protein 2


This article has been cited by other articles:


Home page
 Toxicol SciHome page
C. D. Klaassen and H. Lu
Xenobiotic Transporters: Ascribing Function from Gene Knockout and Mutation Studies
Toxicol. Sci., February 1, 2008; 101(2): 186 - 196.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. L. VanWert, R. M. Bailey, and D. H. Sweet
Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G
Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1332 - F1341.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Ljubojevic, D. Balen, D. Breljak, M. Kusan, N. Anzai, A. Bahn, G. Burckhardt, and I. Sabolic
Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones
Am J Physiol Renal Physiol, January 1, 2007; 292(1): F361 - F372.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. V. St-Pierre, T. Stallmach, A. Freimoser Grundschober, J.-F. Dufour, M. A. Serrano, J. J. G. Marin, Y. Sugiyama, and P. J. Meier
Temporal expression profiles of organic anion transport proteins in placenta and fetal liver of the rat
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1505 - R1516.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
N. Mizuno, T. Niwa, Y. Yotsumoto, and Y. Sugiyama
Impact of Drug Transporter Studies on Drug Discovery and Development
Pharmacol. Rev., September 1, 2003; 55(3): 425 - 461.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
Y. Kato, K. Kuge, H. Kusuhara, P. J. Meier, and Y. Sugiyama
Gender Difference in the Urinary Excretion of Organic Anions in Rats
J. Pharmacol. Exp. Ther., August 1, 2002; 302(2): 483 - 489.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online