AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 282: E1110-E1118, 2002. First published January 22, 2002; doi:10.1152/ajpendo.00442.2001
0193-1849/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/5/E1110    most recent
00442.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chesnokova, V.
Right arrow Articles by Melmed, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chesnokova, V.
Right arrow Articles by Melmed, S.
Vol. 282, Issue 5, E1110-E1118, May 2002

Opposing effects of pituitary leukemia inhibitory factor and SOCS-3 on the ACTH axis response to inflammation

Vera Chesnokova, Anastasia Kariagina, and Shlomo Melmed

Cedars-Sinai Research Institute-University of California Los Angeles School of Medicine, Los Angeles, California 90048

We have shown that leukemia inhibitory factor (LIF) and suppressor of cytokine signaling (SOCS)-3 are expressed in the hypothalamus and pituitary and that LIF induces proopiomelanocortin (POMC) and ACTH, whereas SOCS-3 abrogates corticotroph POMC gene transcription and ACTH secretion. Here, we determined the role of pituitary LIF and SOCS-3 in regulating hypothalamo-pituitary-adrenal (HPA) axis inflammatory responses. Murine pituitary LIF expression was induced up to eightfold after intraperitoneal injection of lipopolysaccharide or tumor necrosis factor-alpha , concordant with elevated plasma levels of ACTH and corticosterone. In LIF knockout (LIFKO) mice, induction of both ACTH and corticosterone were attenuated. LIF deletion was associated with elevated (P < 0.05) levels of pituitary TNF-alpha , interleukin (IL)-1beta , and IL-6 mRNA and cytokine-inducible pituitary SOCS-3 expression. Abrogation of the HPA axis stress response and higher pituitary levels of proinflammatory cytokines observed in LIFKO mice resulted in a stronger inflammatory process, as evidenced by elevated erythrocyte sedimentation rate and increased serum amyloid A levels (P < 0.05). The results indicate that, although LIF induces ACTH, SOCS-3 acts to counterregulate the HPA axis response to inflammation.

hypothalamo-pituitary-adrenal axis; suppressor of cytokine signaling-3; inflammation


This article has been cited by other articles:


Home page
 Exp PhysiolHome page
J. Gerez, J. Bonfiglio, S. Sosa, D. Giacomini, M. Acuna, A. Carbia Nagashima, M. J. Perone, S. Silberstein, U. Renner, G. K. Stalla, et al.
Molecular transduction mechanisms of cytokine-hormone interactions: role of gp130 cytokines
Exp Physiol, September 1, 2007; 92(5): 801 - 806.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. Kariagina, S. Zonis, M. Afkhami, D. Romanenko, and V. Chesnokova
Leukemia inhibitory factor regulates glucocorticoid receptor expression in the hypothalamic-pituitary-adrenal axis
Am J Physiol Endocrinol Metab, November 1, 2005; 289(5): E857 - E863.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
D. Metcalf
The Unsolved Enigmas of Leukemia Inhibitory Factor
Stem Cells, January 1, 2003; 21(1): 5 - 14.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online