AJP - Endo AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 282: E911-E916, 2002. First published November 27, 2001; doi:10.1152/ajpendo.00328.2001
0193-1849/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/4/E911    most recent
00328.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (43)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ostlund, R. E.
Right arrow Articles by Spilburg, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ostlund, R. E., Jr.
Right arrow Articles by Spilburg, C. A.
Vol. 282, Issue 4, E911-E916, April 2002

Gastrointestinal absorption and plasma kinetics of soy Delta 5-phytosterols and phytostanols in humans

Richard E. Ostlund Jr.1, Janet B. McGill1, Chun-Min Zeng3, Douglas F. Covey3, Jay Stearns5, William F. Stenson2, and Curtis A. Spilburg4

Divisions of 1 Endocrinology, Diabetes and Metabolism, and 2 Gastroenterology, Department of Medicine, Washington University School of Medicine, and 3 Department of Molecular Biology and Pharmacology, Washington University, St. Louis 63110; 4 Lifeline Technologies Inc., Chesterfield, Missouri 63017; and 5 Seres Laboratories, Santa Rosa, California 95403

Our objective was to measure the systemic absorption of lecithin-emulsified Delta 5-phytosterols and phytostanols during test meals by use of dual stable isotopic tracers. Ten healthy subjects underwent two single-meal absorption tests in random order 2 wk apart, one with intravenous dideuterated Delta 5-phytosterols and oral pentadeuterated Delta 5-phytosterols and the other with the corresponding labeled stanols. The oral-to-intravenous tracer ratio in plasma, a reflection of absorption, was measured by a sensitive negative ion mass spectroscopic technique and became constant after 2 days. Absorption from 600 mg of Delta 5-soy sterols given with a standard test breakfast was 0.512 ± 0.038% for sitosterol and 1.89 ± 0.27% for campesterol. The absorption from 600 mg of soy stanols was 0.0441 ± 0.004% for sitostanol and 0.155 ± 0.017% for campestanol. Reduction of the double bond at position 5 decreased absorption by 90%. Plasma t1/2 for stanols was significantly shorter than that for Delta 5-sterols. We conclude that the efficiency of phytosterol absorption is lower than what was reported previously and is critically dependent on the structure of both sterol nucleus and side chain.

diet; sitosterol; campesterol; sitostanol; campestanol; clinical study; mass spectrometry; deuterium; cholesterol


This article has been cited by other articles:


Home page
 J. Lipid Res.Home page
S. Pinedo, M. N. Vissers, K. v. Bergmann, K. Elharchaoui, D. Lutjohann, R. Luben, N. J. Wareham, J. J. P. Kastelein, K.-T. Khaw, and S. M. Boekholdt
Plasma levels of plant sterols and the risk of coronary artery disease: the prospective EPIC-Norfolk Population Study
J. Lipid Res., January 1, 2007; 48(1): 139 - 144.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
E. J. Westover, X. Lin, T. E. Riehl, L. Ma, W. F. Stenson, D. F. Covey, and R. E. Ostlund Jr.
Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters
J. Lipid Res., November 1, 2006; 47(11): 2374 - 2381.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
J. Plat, M. C. E. Bragt, and R. P. Mensink
Common sequence variations in ABCG8 are related to plant sterol metabolism in healthy volunteers
J. Lipid Res., January 1, 2005; 46(1): 68 - 75.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
F. J. Field, E. Born, and S. N. Mathur
Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression
J. Lipid Res., December 1, 2004; 45(12): 2252 - 2259.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
P. O. Kwiterovich Jr., S. C. Chen, D. G. Virgil, A. Schweitzer, D. R. Arnold, and L. E. Kratz
Response of obligate heterozygotes for phytosterolemia to a low-fat diet and to a plant sterol ester dietary challenge
J. Lipid Res., June 1, 2003; 44(6): 1143 - 1155.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online