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Am J Physiol Endocrinol Metab 282: E733-E738, 2002;
0193-1849/02 $5.00
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Vol. 282, Issue 3, E733-E738, March 2002

RAPID COMMUNICATION
Identification of a novel glucose transporter-like protein---GLUT-12

Suzanne Rogers1, Maria L. Macheda1, Susan E. Docherty1, Maynard D. Carty2, Michael A. Henderson3, Walter C. Soeller2, E. Michael Gibbs2, David E. James4, and James D. Best1

Departments of 1 Medicine and 3 Surgery, The University of Melbourne, St. Vincent's Hospital Melbourne, Fitzroy, Victoria 3065; 4 Institute for Molecular Bioscience, University of Queensland, St. Lucia, Queensland, Australia 4072; and 2 Department of Cardiovascular Metabolic Diseases, Pfizer Global Research and Development, Pfizer Incorporated, Groton, Connecticut 06340

Facilitative glucose transporters exhibit variable hexose affinity and tissue-specific expression. These characteristics contribute to specialized metabolic properties of cells. Here we describe the characterization of a novel glucose transporter-like molecule, GLUT-12. GLUT-12 was identified in MCF-7 breast cancer cells by homology to the insulin-regulatable glucose transporter GLUT-4. The GLUT-12 cDNA encodes 617 amino acids, which possess features essential for sugar transport. Di-leucine motifs are present in NH2 and COOH termini at positions similar to the GLUT-4 FQQI and LL targeting motifs. GLUT-12 exhibits 29% amino acid identity with GLUT-4 and 40% to the recently described GLUT-10. Like GLUT-10, a large extracellular domain is predicted between transmembrane domains 9 and 10. Genomic organization of GLUT-12 is highly conserved with GLUT-10 but distinct from GLUTs 1-5. Immunofluorescence showed that, in the absence of insulin, GLUT-12 is localized to the perinuclear region in MCF-7 cells. Immunoblotting demonstrated GLUT-12 expression in skeletal muscle, adipose tissue, and small intestine. Thus GLUT-12 is potentially part of a second insulin-responsive glucose transport system.

facilitative glucose transporter; insulin-responsive tissues; breast cancer


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