AJP - Endo Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 282: E703-E713, 2002. First published October 2, 2001; doi:10.1152/ajpendo.00072.2001
0193-1849/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Table
Right arrow All Versions of this Article:
282/3/E703    most recent
00072.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (31)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gregoire, F. M.
Right arrow Articles by West, D. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gregoire, F. M.
Right arrow Articles by West, D. B.
Vol. 282, Issue 3, E703-E713, March 2002

Diet-induced obesity and hepatic gene expression alterations in C57BL/6J and ICAM-1-deficient mice

Francine M. Gregoire*, Qin Zhang*, Steven J. Smith, Carmen Tong, David Ross, Henry Lopez, and David B. West

Pfizer Global R&D, Alameda, California 94502

The effects of high-fat feeding on the development of obesity were evaluated in intercellular adhesion molecule-1 (ICAM-1) knockout and C57BL/6J (B6) male mice fed a high-fat diet for <= 50 days. Serum and tissues were collected at baseline and after 1, 11, and 50 days on the diet. After 11 days on the diet, ICAM-1-deficient, but not B6, mice developed fatty livers and showed a significant increase in inguinal fat pad weight. At day 50, ICAM-1-deficient mice weighed less, and their adiposity index and circulating leptin levels were significantly lower than those of B6 controls. To better understand the early differential response to the diet, liver gene expression was analyzed at three time points by use of Affymetrix GeneChips. In both strains, a similar pattern of gene expression was detected in response to the high-fat diet. However, sterol regulatory element-binding protein-1, apolipoprotein A4, and adipsin mRNAs were significantly induced in ICAM-1-deficient livers, suggesting that these genes and their associated pathways may be involved in the acute diet response observed in the knockout mice.

intercellular adhesion molecule-1 knockout mice; obesity; dyslipidemia; steatosis; microarray

* These authors contributed equally.




This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
S. Lu and M. C. Archer
Celecoxib Decreases Fatty Acid Synthase Expression via Down-Regulation of c-Jun N-Terminal Kinase-1
Experimental Biology and Medicine, May 1, 2007; 232(5): 643 - 653.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
J. J. Loor, H. M. Dann, R. E. Everts, R. Oliveira, C. A. Green, N. A. J. Guretzky, S. L. Rodriguez-Zas, H. A. Lewin, and J. K. Drackley
Temporal gene expression profiling of liver from periparturient dairy cows reveals complex adaptive mechanisms in hepatic function
Physiol Genomics, October 17, 2005; 23(2): 217 - 226.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Kurlawalla-Martinez, B. Stiles, Y. Wang, S. U. Devaskar, B. B. Kahn, and H. Wu
Insulin Hypersensitivity and Resistance to Streptozotocin-Induced Diabetes in Mice Lacking PTEN in Adipose Tissue
Mol. Cell. Biol., March 15, 2005; 25(6): 2498 - 2510.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
A. Recinos III, B. K. Carr, D. B. Bartos, I. Boldogh, J. R. Carmical, L. M. Belalcazar, and A. R. Brasier
Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway
Physiol Genomics, September 16, 2004; 19(1): 131 - 142.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
S. M. Watkins, P. R. Reifsnyder, H.-j. Pan, J. B. German, and E. H. Leiter
Lipid metabolome-wide effects of the PPAR{gamma} agonist rosiglitazone
J. Lipid Res., November 1, 2002; 43(11): 1809 - 1817.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online