AJP - Endo AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 282: E650-E656, 2002; doi:10.1152/ajpendo.00388.2001
0193-1849/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johnson, P. M.
Right arrow Articles by Muglia, L. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johnson, P. M.
Right arrow Articles by Muglia, L. J.
Vol. 282, Issue 3, E650-E656, March 2002

COX-2 inhibition attenuates anorexia during systemic inflammation without impairing cytokine production

Paulette M. Johnson, Sherri K. Vogt, Mary W. Burney, and Louis J. Muglia

Departments of Pediatrics, Molecular Biology and Pharmacology, and Obstetrics and Gynecology, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri 63110

Anorexia and weight loss are frequent complications of acute and chronic infections and result from induction of cytokines, prostaglandins, and other inflammatory mediators that are critical for pathogen elimination. Selective attenuation of the hypophagic response to infection and maintenance of the production of factors essential for infection control would be a useful addition to antimicrobial therapy in the treatment of human disease. Here, we evaluate the relative contribution of cyclooxygenase (COX)-1- and COX-2-derived prostaglandins to anorexia and weight loss precipitated by systemic immune activation by lipopolysaccharide (LPS). Using COX isoform-selective pharmacological inhibitors and gene knockout mice, we found that COX-2 inhibition during LPS-induced inflammation results in preserved food intake and maintenance of body weight, whereas COX-1 inhibition results in augmented and prolonged weight loss. Regulation of neuropeptide Y, corticotropin-releasing hormone, leptin, and interleukin-6 does not change as a function of COX-2 inhibition after LPS administration. Our data implicate COX-2 inhibition as a therapeutic target to maintain nutritional status while still allowing a normal cytokine response during infection.

nonsteroidal anti-inflammatory drugs; knockout mice; appetite; cyclooxygenase-2


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. Hayashi, H. B. Cottam, M. Chan, G. Jin, R. I. Tawatao, B. Crain, L. Ronacher, K. Messer, D. A. Carson, and M. Corr
Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R123 - R132.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Granado, A. I Martin, M{a} A. Villanua, and A. Lopez-Calderon
Experimental arthritis inhibits the insulin-like growth factor-I axis and induces muscle wasting through cyclooxygenase-2 activation
Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1656 - E1665.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Elander, L. Engstrom, M. Hallbeck, and A. Blomqvist
IL-1beta and LPS induce anorexia by distinct mechanisms differentially dependent on microsomal prostaglandin E synthase-1
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R258 - R267.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
E. Pecchi, M. Dallaporta, S. Thirion, C. Salvat, F. Berenbaum, A. Jean, and J.-D. Troadec
Involvement of central microsomal prostaglandin E synthase-1 in IL-1{beta}-induced anorexia
Physiol Genomics, May 16, 2006; 25(3): 485 - 492.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
P. S. Biswas, K. Banerjee, B. Kim, P. R. Kinchington, and B. T. Rouse
Role of Inflammatory Cytokine-Induced Cycloxygenase 2 in the Ocular Immunopathologic Disease Herpetic Stromal Keratitis
J. Virol., August 15, 2005; 79(16): 10589 - 10600.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
T. W. Davis, B. S. Zweifel, J. M. O'Neal, D. M. Heuvelman, A. L. Abegg, T. O. Hendrich, and J. L. Masferrer
Inhibition of Cyclooxygenase-2 by Celecoxib Reverses Tumor-Induced Wasting
J. Pharmacol. Exp. Ther., March 1, 2004; 308(3): 929 - 934.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
F. Lugarini, B. J. Hrupka, G. J. Schwartz, C. R. Plata-Salaman, and W. Langhans
A role for cyclooxygenase-2 in lipopolysaccharide-induced anorexia in rats
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2002; 283(4): R862 - R868.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
A. H. Swiergiel and A. J. Dunn
Distinct Roles for Cyclooxygenases 1 and 2 in Interleukin-1-Induced Behavioral Changes
J. Pharmacol. Exp. Ther., September 1, 2002; 302(3): 1031 - 1036.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online