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Department of Human Physiology, Copenhagen Muscle Research Centre, University of Copenhagen, DK-2100 Copenhagen, Denmark
The resting content and use of
myocellular triacylglycerol (MCTG) during 90 min of submaximal exercise
[60% of peak oxygen uptake
(
O2 peak)] were studied in 21 eumenorrheic female and 21 male subjects at different training levels
[untrained (UT), moderately trained (MT), and endurance trained
(END)]. Males and females were matched according to their
O2 peak expressed relative to lean body
mass, physical activity level, and training history. All subjects
ingested the same controlled diet for 8 days, and all females were
tested in the midfollicular phase of the menstrual cycle. Resting MCTG,
measured with the muscle biopsy technique, averaged 48.4 ± 4.2, 48.5 ± 8.4, and 52.2 ± 5.8 mmol/kg dry wt in UT, MT, and
END females, respectively, and 34.1 ± 4.9, 31.6 ± 3.3, and
38.4 ± 3.0 mmol/kg dry wt in UT, MT, and END males, respectively
(P < 0.001, females vs. males in all groups). Exercise decreased MCTG content in the female subjects by an average of 25%,
regardless of training status, whereas in the male groups MCTG content
was unaffected by exercise. The arterial plasma insulin concentration
was higher (P < 0.05) and the arterial plasma
epinephrine concentration was lower (P < 0.05) in the
females than in the males at rest and during exercise. MCTG use was
correlated to the resting concentration of MCTG (P < 0.001). We conclude that resting content and use of MCTG during
exercise are related to gender and furthermore are independent of
training status.
muscle substrate; training; triglycerides
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