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Am J Physiol Endocrinol Metab 282: E626-E633, 2002; doi:10.1152/ajpendo.00346.2001
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Vol. 282, Issue 3, E626-E633, March 2002

Lipid metabolism and resistin gene expression in insulin-resistant Fischer 344 rats

James R. Levy1,2, Byrd Davenport2, John N. Clore2, and Wayne Stevens1

1 Section of Endocrinology and Metabolism, McGuire Veterans Administration Medical Center and 2 Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23249

The interrelationship between insulin and leptin resistance in young Fischer 344 (F344) rats was studied. Young F344 and Sprague-Dawley (SD) rats were fed regular chow. F344 animals had two- to threefold higher insulin and triglyceride concentrations and increased stores of triglycerides within liver and muscle. F344 animals gained more body fat. Both acyl-CoA oxidase (ACO) and carnitine palmitoyltransferase I gene expression were 20-50% less in F344 animals than in age-matched SD animals. Peroxisome proliferator-activated receptor-alpha gene expression was reduced in 70-day-old F344 animals. Finally, resistin gene expression was similar in 70-day-old SD and F344 animals. Resistin gene expression increased fivefold in F344 animals and twofold in SD animals from 70 to 130 days, without a change in insulin sensitivity. We conclude that young F344 animals have both insulin and leptin resistance, which may lead to diminished fatty oxidation and accumulation of triglycerides in insulin-sensitive target tissues. We did not detect a role for resistin in the etiology of insulin resistance in F344 animals.

Fischer 344 rats; acyl-coenzyme A oxidase; carnitine palmitoyltransferase I; peroxisome proliferator-activated receptor-alpha


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