| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Nutrition, Metabolism, and Exercise Laboratory, Donald W. Reynolds Center on Aging, Departments of Geriatrics and Physiology and Biophysics, University of Arkansas for Medical Sciences, and the Central Arkansas Veterans HealthCare System, Little Rock, Arkansas 72205; and 2 Department of Nutritional Sciences, University of California, Berkeley, California 94720-3104
We examined the effect of two commonly consumed over-the-counter analgesics, ibuprofen and acetaminophen, on muscle protein synthesis and soreness after high-intensity eccentric resistance exercise. Twenty-four males (25 ± 3 yr, 180 ± 6 cm, 81 ± 6 kg, and 17 ± 8% body fat) were assigned to one of three groups that received either the maximal over-the-counter dose of ibuprofen (IBU; 1,200 mg/day), acetaminophen (ACET; 4,000 mg/day), or a placebo (PLA) after 10-14 sets of 10 eccentric repetitions at 120% of concentric one-repetition maximum with the knee extensors. Postexercise (24 h) skeletal muscle fractional synthesis rate (FSR) was increased 76 ± 19% (P < 0.05) in PLA (0.058 ± 0.012%/h) and was unchanged (P > 0.05) in IBU (35 ± 21%; 0.021 ± 0.014%/h) and ACET (22 ± 23%; 0.010 ± 0.019%/h). Neither drug had any influence on whole body protein breakdown, as measured by rate of phenylalanine appearance, on serum creatine kinase, or on rating of perceived muscle soreness compared with PLA. These results suggest that over-the-counter doses of both ibuprofen and acetaminophen suppress the protein synthesis response in skeletal muscle after eccentric resistance exercise. Thus these two analgesics may work through a common mechanism to influence protein metabolism in skeletal muscle.
paracetamol; analgesics; nonsteroidal anti-inflammatory agents; delayed-onset muscle soreness
This article has been cited by other articles:
|
|
 |
|
  M. M. Robinson, K. L. Hamilton, and B. F. Miller The interactions of some commonly consumed drugs with mitochondrial adaptations to exercise J Appl Physiol, July 1, 2009; 107(1): 8 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L Novak, W. Billich, S. M. Smith, K. B. Sukhija, T. J. McLoughlin, T. A. Hornberger, and T. J. Koh COX-2 inhibitor reduces skeletal muscle hypertrophy in mice Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R1132 - R1139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Tscholl, N. Feddermann, A. Junge, and J. Dvorak The Use and Abuse of Painkillers in International Soccer: Data From 6 FIFA Tournaments for Female and Youth Players Am. J. Sports Med., February 1, 2009; 37(2): 260 - 265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Trappe, C. C. Carroll, B. Jemiolo, S. W. Trappe, S. Dossing, M. Kjaer, and S. P. Magnusson Cyclooxygenase mRNA expression in human patellar tendon at rest and after exercise Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R192 - R199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Testa, B. Rocca, L. Spath, F. O. Ranelletti, G. Petrucci, G. Ciabattoni, F. Naro, S. Schiaffino, M. Volpe, and C. Reggiani Expression and activity of cyclooxygenase isoforms in skeletal muscles and myocardium of humans and rodents J Appl Physiol, October 1, 2007; 103(4): 1412 - 1418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. DiPasquale, M. Cheng, W. Billich, S. A. Huang, N. van Rooijen, T. A. Hornberger, and T. J. Koh Urokinase-type plasminogen activator and macrophages are required for skeletal muscle hypertrophy in mice Am J Physiol Cell Physiol, October 1, 2007; 293(4): C1278 - C1285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Mackey, M. Kjaer, S. Dandanell, K. H. Mikkelsen, L. Holm, S. Dossing, F. Kadi, S. O. Koskinen, C. H. Jensen, H. D. Schroder, et al. The influence of anti-inflammatory medication on exercise-induced myogenic precursor cell responses in humans J Appl Physiol, August 1, 2007; 103(2): 425 - 431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Bamman Take two NSAIDs and call on your satellite cells in the morning J Appl Physiol, August 1, 2007; 103(2): 415 - 416. [Full Text] [PDF]
|
|
|
|
|
|
H. F. Kramer and L. J. Goodyear Exercise, MAPK, and NF-{kappa}B signaling in skeletal muscle J Appl Physiol, July 1, 2007; 103(1): 388 - 395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Weinheimer, B. Jemiolo, C. C. Carroll, M. P. Harber, J. M. Haus, N. A. Burd, J. K. LeMoine, S. W. Trappe, and T. A. Trappe Resistance exercise and cyclooxygenase (COX) expression in human skeletal muscle: implications for COX-inhibiting drugs and protein synthesis Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2007; 292(6): R2241 - R2248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Eliasson, T. Elfegoun, J. Nilsson, R. Kohnke, B. Ekblom, and E. Blomstrand Maximal lengthening contractions increase p70 S6 kinase phosphorylation in human skeletal muscle in the absence of nutritional supply Am J Physiol Endocrinol Metab, December 1, 2006; 291(6): E1197 - E1205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Bondesen, S. T. Mills, and G. K. Pavlath The COX-2 pathway regulates growth of atrophied muscle via multiple mechanisms Am J Physiol Cell Physiol, June 1, 2006; 290(6): C1651 - C1659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Carroll, J. D. Fluckey, R. H. Williams, D. H. Sullivan, and T. A. Trappe Human soleus and vastus lateralis muscle protein metabolism with an amino acid infusion Am J Physiol Endocrinol Metab, March 1, 2005; 288(3): E479 - E485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Evans Protein Nutrition, Exercise and Aging J. Am. Coll. Nutr., December 1, 2004; 23(suppl_6): 601S - 609S. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
