AJP - Endo Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 282: E458-E465, 2002. First published October 2, 2001; doi:10.1152/ajpendo.00287.2001
0193-1849/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/2/E458    most recent
00287.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (14)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sage, D.
Right arrow Articles by Bosler, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sage, D.
Right arrow Articles by Bosler, O.
Vol. 282, Issue 2, E458-E465, February 2002

Corticosterone-dependent driving influence of the suprachiasmatic nucleus on adrenal sensitivity to ACTH

Dominique Sage, Daniel Maurel, and Olivier Bosler

Interactions Fonctionnelles en Neuroendocrinologie, Institut National de la Santé et de la Recherche Médicale, Institut Fédératif Jean-Roche, Université de la Méditerranée, 13916 Marseille, France

We investigated the effects of ablation of the suprachiasmatic nucleus (SCN) on corticosterone (CORT) responses to synthetic ACTH given in either the morning or evening. After dexamethasone treatment, evening ACTH injections in intact rats produced a significantly larger increase in plasma CORT compared with morning ones. In rats with SCN lesions, the ACTH-induced CORT secretion was independent of time of day, providing direct evidence for a driving influence of the SCN on the diurnal rhythm of adrenal sensitivity to ACTH. In the absence of dexamethasone treatment, the SCN-lesioned rats were selected for morning-like (ML) or evening-like (EL) basal levels of CORT. Responses to ACTH were not different in ML rats compared with sham-lesioned morning controls. In contrast, EL rats compared with sham-lesioned evening controls showed an ~60% decrease in increment of CORT levels within the first 15 min postinjection. These results indicate that the SCN upregulates ACTH sensitivity of the adrenal cortex during the ascending phase of the daily CORT secretion and point to a critical role of glucocorticoids in determining SCN action.

adrenocorticotropin hormone; hypothalamic-pituitary-adrenal axis; circadian rhythm; glucocorticoids; adrenal cortex


This article has been cited by other articles:


Home page
 J EndocrinolHome page
T. Dickmeis
Glucocorticoids and the circadian clock
J. Endocrinol., January 1, 2009; 200(1): 3 - 22.
[Abstract] [Full Text] [PDF]

Home page
 J PsychopharmacolHome page
S.A. Hesketh, J.D. Leggett, and D.S. Jessop Henry
Chronic citalopram treatment does not sensitize the adrenal gland to ACTH (1 24) in rats
J Psychopharmacol, November 1, 2007; 21(8): 885 - 887.
[Abstract] [PDF]

Home page
 J. Physiol.Home page
S. Banjanin, A. Kapoor, and S. G. Matthews
Prenatal glucocorticoid exposure alters hypothalamic-pituitary-adrenal function and blood pressure in mature male guinea pigs
J. Physiol., July 1, 2004; 558(1): 305 - 318.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online