AJP - Endo Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 282: E304-E311, 2002; doi:10.1152/ajpendo.00333.2001
0193-1849/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tessari, P.
Right arrow Articles by Zanetti, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tessari, P.
Right arrow Articles by Zanetti, M.
Vol. 282, Issue 2, E304-E311, February 2002

Impairment of albumin and whole body postprandial protein synthesis in compensated liver cirrhosis

P. Tessari1,3, R. Barazzoni1, E. Kiwanuka1, G. Davanzo1, G. De Pergola3, R. Orlando2, M. Vettore1, and M. Zanetti1

1 Department of Clinical and Experimental Medicine, Chair of Metabolism, and 2 Department of Internal Medicine, University of Padova, 35128 Padua; and 3 Department of Internal Medicine and Endocrinology, University of Bari, 70124 Bari, Italy

To investigate the anabolic effects of feeding in cirrhosis, we measured albumin fractional synthesis rate (FSR) and whole body protein synthesis in six nondiabetic patients with stable liver cirrhosis (three in the Child-Pugh classification Class A, three in Class B) and in seven normal control subjects, before and after administration of a 4-h mixed meal. Leucine tracer precursor-product relationships and whole body kinetics were employed at steady state. Basal levels of postabsorptive albumin concentration and FSR, whole body leucine rate of appearance, oxidation, and nonoxidative leucine disposal (NOLD, approx protein synthesis) were similar in the two groups. However, after the meal, in the patients neither albumin FSR (from 8.5 ± 1.5 to 8.8 ± 1.8 %/day) nor NOLD (from 1.69 ± 0.22 to 1.55 ± 0.26 µmol · kg-1 · min-1) changed (P = nonsignificant vs. basal), whereas they increased in control subjects (albumin FSR: from 10.9 ± 1.5 to 15.9 ± 1.9 %/day, P < 0.002; NOLD: from 1.80 ± 0.14 to 2.10 ± 0.19 µmol · kg-1 · min-1, P = 0.032). Thus mixed meal ingestion did not stimulate either albumin FSR or whole body protein synthesis in compensated liver cirrhosis. The mechanism(s) maintaining normoalbuminemia at this disease stage need to be further investigated.

albumin synthesis; nonoxidative leucine disposal; meal ingestion; alpha -ketoisocaproate; specific activity; compensated cirrhosis


This article has been cited by other articles:


Home page
 JPEN J Parenter Enteral NutrHome page
S. Dasarathy
Inflammation and Liver
JPEN J Parenter Enteral Nutr, November 1, 2008; 32(6): 660 - 666.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
P. Tessari, E. Kiwanuka, M. Vettore, R. Barazzoni, M. Zanetti, D. Cecchet, and R. Orlando
Phenylalanine and tyrosine kinetics in compensated liver cirrhosis: effects of meal ingestion
Am J Physiol Gastrointest Liver Physiol, September 1, 2008; 295(3): G598 - G604.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
D. R. Mager, L. J. Wykes, E. A. Roberts, R. O. Ball, and P. B. Pencharz
Mild-to-Moderate Chronic Cholestatic Liver Disease Increases Leucine Oxidation in Children
J. Nutr., April 1, 2006; 136(4): 965 - 970.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. F. Previs, R. Fatica, V. Chandramouli, J. C. Alexander, H. Brunengraber, and B. R. Landau
Quantifying rates of protein synthesis in humans by use of 2H2O: application to patients with end-stage renal disease
Am J Physiol Endocrinol Metab, April 1, 2004; 286(4): E665 - E672.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online