| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115
We investigated the relationship between sleep timing and the timing of the circadian rhythm of plasma melatonin secretion in a group of healthy young and older subjects without sleep complaints. The timing of sleep and the phase of the circadian melatonin rhythm were earlier in the older subjects. The relationship between the plasma melatonin rhythm and the timing of sleep was such that the older subjects were sleeping and waking earlier relative to their nightly melatonin secretory episode. Consequently, the older subjects were waking at a time when they had higher relative melatonin levels, in contrast with younger subjects, whose melatonin levels were relatively lower by wake time. Our findings indicate that aging is associated not only with an advance of sleep timing and the timing of circadian rhythms but also with a change in the internal phase relationship between the sleep-wake cycle and the output of the circadian pacemaker. In healthy older subjects, the relative timing of the melatonin rhythm with respect to sleep may not play a causal role in sleep disruption.
aging; biological rhythms; chronobiology; constant routine
This article has been cited by other articles:
|
|
 |
|
  A. U. Viola, L. M. James, S. N. Archer, and D.-J. Dijk PER3 polymorphism and cardiac autonomic control: effects of sleep debt and circadian phase Am J Physiol Heart Circ Physiol, November 1, 2008; 295(5): H2156 - H2163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H. Monk Aging Human Circadian Rhythms: Conventional Wisdom May Not Always Be Right J Biol Rhythms, August 1, 2005; 20(4): 366 - 374. [Abstract] [PDF]
|
|
|
|
|
|
S. Benloucif, M. J. Guico, K. J. Reid, L. F. Wolfe, M. L'Hermite-Baleriaux, and P. C. Zee Stability of Melatonin and Temperature as Circadian Phase Markers and Their Relation to Sleep Times in Humans J Biol Rhythms, April 1, 2005; 20(2): 178 - 188. [Abstract] [PDF]
|
|
|
|
|
|
J. Taillard, P. Philip, J.-F. Chastang, and B. Bioulac Validation of Horne and Ostberg Morningness-Eveningness Questionnaire in a Middle-Aged Population of French Workers J Biol Rhythms, February 1, 2004; 19(1): 76 - 86. [Abstract] [PDF]
|
|
|
|
|
|
M. Perret, F. Aujard, M. Seguy, and A. Schilling Olfactory Bulbectomy Modifies Photic Entrainment and Circadian Rhythms of Body Temperature and Locomotor Activity in a Nocturnal Primate J Biol Rhythms, October 1, 2003; 18(5): 392 - 401. [Abstract] [PDF]
|
|
|
|
 |
|
 S. B. S Khalsa, M. E Jewett, C. Cajochen, and C. A Czeisler A phase response curve to single bright light pulses in human subjects J. Physiol., June 15, 2003; 549(3): 945 - 952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Baehr, C. I. Eastman, W. Revelle, S. H. L. Olson, L. F. Wolfe, and P. C. Zee Circadian phase-shifting effects of nocturnal exercise in older compared with young adults Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1542 - R1550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. P. Wright Jr., J. T. Hull, and C. A. Czeisler Relationship between alertness, performance, and body temperature in humans Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2002; 283(6): R1370 - R1377. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
