AJP - Endo Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 282: E59-E66, 2002;
0193-1849/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (29)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hainault, I.
Right arrow Articles by Quignard-Boulangé, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hainault, I.
Right arrow Articles by Quignard-Boulangé, A.
Vol. 282, Issue 1, E59-E66, January 2002

Adipose tissue-specific increase in angiotensinogen expression and secretion in the obese (fa/fa) Zucker rat

Isabelle Hainault, Guillaume Nebout, Sophie Turban, Bernadette Ardouin, Pascal Ferré, and Annie Quignard-Boulangé

Institut National de la Santé et de la Recherche Médicale U 465, Centre Biomédical des Cordeliers, Université Pierre et Marie Curie, 15 rue de l'Ecole de Médecine, 75270 Paris, France

We investigated angiotensinogen (AGT) expression in adipose tissue and liver of Zucker rats during the onset of obesity. The developmental pattern of AGT expression (protein and mRNA) in liver was similar in both genotypes. In inguinal adipose tissue, AGT cell content was similar in suckling and weaned pups in lean rats, whereas it continuously increased with age in obese rats. AGT amount in adipocytes was unaffected by the genotype until weaning. Thereafter, adipocytes from obese rats displayed a significant increase in AGT content that was strengthened with age. Compared with the cell content, the amount of secreted AGT over 24 h was higher, and a genotype effect was observed as early as 14 days of age. Using fat cell populations differing by size, we showed that this AGT oversecretion was not solely related to adipocyte hypertrophy. Our results demonstrate that the fa genotype exerts a control on the production of AGT in a tissue-specific manner, suggesting a local role of AGT in the overdevelopment of adipose tissue.

adipocyte; leptin; liver; renin; obesity-induced hypertension


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
A. P. Jayasooriya, M. L. Mathai, L. L. Walker, D. P. Begg, D. A. Denton, D. Cameron-Smith, G. F. Egan, M. J. McKinley, P. D. Rodger, A. J. Sinclair, et al.
Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance
PNAS, May 6, 2008; 105(18): 6531 - 6536.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. H. S. Santos, L. R. Fernandes, E. G. Mario, A. V. M. Ferreira, L. C. J. Porto, J. I. Alvarez-Leite, L. M. Botion, M. Bader, N. Alenina, and R. A. S. Santos
Mas Deficiency in FVB/N Mice Produces Marked Changes in Lipid and Glycemic Metabolism
Diabetes, February 1, 2008; 57(2): 340 - 347.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
S. O. Kasper, C. S. Carter, C. M. Ferrario, D. Ganten, L. F. Ferder, W. E. Sonntag, P. E. Gallagher, and D. I. Diz
Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems
Physiol Genomics, November 17, 2005; 23(3): 311 - 317.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. Crowley, S. Gurley, M. Oliverio, A. Pazmino, R Griffiths, P. Flannery, R. Spurney, H-S Kim, O Smithies, T. Le, et al.
Is the Kidney Always the Cause of Hypertension?: Distinct Roles for the Kidney and Systemic Tissues in Blood Pressure Regulation by the Renin-Angiotensin System. J Clin Invest 115: 1092-1099, 2005
J. Am. Soc. Nephrol., June 1, 2005; 16(6): 1525 - 1532.
[Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
Y. H. Suh, Y. Kim, J. H. Bang, K. S. Choi, J. W. Lee, W.-H. Kim, T. J. Oh, S. An, and M. H. Jung
Analysis of gene expression profiles in insulin-sensitive tissues from pre-diabetic and diabetic Zucker diabetic fatty rats
J. Mol. Endocrinol., April 1, 2005; 34(2): 299 - 315.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. Rahmouni, A. L. Mark, W. G. Haynes, and C. D. Sigmund
Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity
Am J Physiol Endocrinol Metab, June 1, 2004; 286(6): E891 - E895.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online