AJP - Endo Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 282: E31-E37, 2002;
0193-1849/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (27)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Awede, B. L.
Right arrow Articles by Lebacq, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Awede, B. L.
Right arrow Articles by Lebacq, J.
Vol. 282, Issue 1, E31-E37, January 2002

Role of IGF-I and IGFBPs in the changes of mass and phenotype induced in rat soleus muscle by clenbuterol

Bonaventure L. Awede1, Jean-Paul Thissen2, and Jean Lebacq1

1 Unité de Physiologie Générale des Muscles, and 2 Unité de Diabétologie et Nutrition, Université Catholique de Louvain, 1200 Brussels, Belgium

Clenbuterol induces hypertrophy and a slow-to-fast phenotype change in skeletal muscle, but the signaling mechanisms remain unclear. We hypothesized that clenbuterol could act via local expression of insulin-like growth factor I (IGF-I). Administration of clenbuterol to 3-mo-old female Wistar rats resulted in a 10 and 13% increase of soleus muscle mass after 3 and 9 days, respectively, reaching 16% after 4 wk. When associated with triiodothyronine, clenbuterol induced a dramatic slow-to-fast phenotype change. In parallel, clenbuterol administration induced in soleus muscle a fivefold increase in IGF-I mRNA levels associated with an eightfold increase in IGF-binding protein (IGFBP)-4 and a fivefold increase of IGFBP-5 mRNA levels on day 3. This increased IGF-I gene expression was associated with an increase in muscle IGF-I content, already detected on day 1 and persisting until day 5 without increase in serum IGF-I concentrations. These data show that muscle hypertrophy induced by clenbuterol is associated with a local increase in muscle IGF-I content. They suggest that clenbuterol-induced muscle hypertrophy could be mediated by local production of IGF-I.

insulin-like growth factor; insulin-like growth factor-binding proteins; beta 2-adrenoceptor agonists; hypertrophy; fiber type


This article has been cited by other articles:


Home page
 PhysiologyHome page
M. Sandri
Signaling in Muscle Atrophy and Hypertrophy
Physiology, June 1, 2008; 23(3): 160 - 170.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
O Schakman, H Gilson, and J P Thissen
Mechanisms of glucocorticoid-induced myopathy
J. Endocrinol., April 1, 2008; 197(1): 1 - 10.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. H. Lang, B. J. Krawiec, D. Huber, J. M. McCoy, and R. A. Frost
Sepsis and inflammatory insults downregulate IGFBP-5, but not IGFBP-4, in skeletal muscle via a TNF-dependent mechanism
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R963 - R972.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Yimlamai, S. L. Dodd, S. E. Borst, and S. Park
Clenbuterol induces muscle-specific attenuation of atrophy through effects on the ubiquitin-proteasome pathway
J Appl Physiol, July 1, 2005; 99(1): 71 - 80.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. S. Bickel, J. Slade, E. Mahoney, F. Haddad, G. A. Dudley, and G. R. Adams
Time course of molecular responses of human skeletal muscle to acute bouts of resistance exercise
J Appl Physiol, February 1, 2005; 98(2): 482 - 488.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Beitzel, P. Gregorevic, J. G. Ryall, D. R. Plant, M. N. Sillence, and G. S. Lynch
{beta}2-Adrenoceptor agonist fenoterol enhances functional repair of regenerating rat skeletal muscle after injury
J Appl Physiol, April 1, 2004; 96(4): 1385 - 1392.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
M. A. Pellegrino, G. D'Antona, S. Bortolotto, F. Boschi, O. Pastoris, R. Bottinelli, B. Polla, and C. Reggiani
Clenbuterol antagonizes glucocorticoid-induced atrophy and fibre type transformation in mice
Exp Physiol, January 1, 2004; 89(1): 89 - 100.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. I. Lewis, H. Li, Z.-S. Huang, M. S. Biring, B. Cercek, and M. Fournier
Influence of varying degrees of malnutrition on IGF-I expression in the rat diaphragm
J Appl Physiol, August 1, 2003; 95(2): 555 - 562.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. S. Bickel, J. M. Slade, F. Haddad, G. R. Adams, and G. A. Dudley
Acute molecular responses of skeletal muscle to resistance exercise in able-bodied and spinal cord-injured subjects
J Appl Physiol, June 1, 2003; 94(6): 2255 - 2262.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. E. Spangenburg, T. Abraha, T. E. Childs, J. S. Pattison, and F. W. Booth
Skeletal muscle IGF-binding protein-3 and -5 expressions are age, muscle, and load dependent
Am J Physiol Endocrinol Metab, February 1, 2003; 284(2): E340 - E350.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online