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Am J Physiol Endocrinol Metab 281: E931-E937, 2001;
0193-1849/01 $5.00
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Vol. 281, Issue 5, E931-E937, November 2001

CaMKIV/Gr is dispensable for spermatogenesis and CREM-regulated transcription in male germ cells

Frank Blaeser1, Jorma Toppari5,6, Markku Heikinheimo1,7, Wei Yan6, Mia Wallace2, Nga Ho1, and Talal A. Chatila1,3,4

Departments of 1 Pediatrics, 2 Anatomy and Neurobiology, and 3 Pathology and Immunology, and 4 Center for Immunology, Washington University School of Medicine, St. Louis, Missouri 63110; Departments of 5 Pediatrics and 6 Physiology, University of Turku, 20520 Turku; and 7 Children's Hospital, University of Helsinki, 00290 Helsinki, Finland

The calcium/calmodulin-dependent protein kinase type IV/Gr (CaMKIV/Gr) is expressed in male germ cells and spermatids and has been implicated in controlling the differentiation of germ cells into mature spermatozoa. The function of CaMKIV/Gr in spermatogenesis was investigated using CaMKIV/Gr-deficient mice generated by targeted gene disruption. CaMKIV/Gr-deficient males exhibited normal spermatogenesis, and their fertility was similar to that of wild-type littermates. Notwithstanding the function of CaMKIV/Gr as an activator of cAMP response element (CRE)-dependent transcription, mRNA levels of several testis-specific CRE modulator (CREM)-regulated genes were unaltered. These results indicate that CaMKIV/Gr is not essential for spermatogenesis or for CRE-regulated gene transcription in the testis.

calcium signaling; calmodulin-dependent protein kinase; spermiogenesis; cyclic adenosine monophosphate response element modulator


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