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1 Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35233; and 2 Department of Surgery, The University of Michigan Medical School, and the C. S. Mott Children's Hospital, Ann Arbor, Michigan 48109
Fatty acid translocase (FAT)/CD36 is one of several putative plasma membrane long-chain fatty acid (LCFA) transport proteins; however, its role in intestinal absorption of LCFA is unknown. We hypothesized that FAT/CD36 would be differentially expressed along the longitudinal axis of the gut and during intestinal development, suggesting specificity of function. We found that intestinal mucosal FAT/CD36 mRNA levels varied by anatomic location along the longitudinal gut axis: stomach 45 ± 7, duodenum 173 ± 29, jejunum 238 ± 17, ileum 117 ± 14, and colon 9 ± 1% (means ± SE with 18S mRNA as control). FAT/CD36 protein levels were also higher in proximal compared with distal intestinal mucosa. Mucosal FAT/CD36 mRNA was also regulated during intestinal maturation, with a fourfold increase from neonatal to adult animals. In addition, FAT/CD36 mRNA levels and enterocyte LCFA uptake were rapidly downregulated by intraduodenal oleate infusion. These findings suggest that FAT/CD36 plays a role in the uptake of LCFA by small intestinal enterocytes. This may have important implications in understanding fatty acid absorption in human physiological and pathophysiological conditions.
fatty acid translocase/CD36; intestine; transport of fatty acids
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