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Am J Physiol Endocrinol Metab 281: E1088-E1094, 2001;
0193-1849/01 $5.00
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Vol. 281, Issue 5, E1088-E1094, November 2001

Thyroid hormone induces cerebellar astrocytes and C6 glioma cells to secrete mitogenic growth factors

A. G. Trentin1, M. Alvarez-Silva1, and V. Moura Neto2

1 Departamento de Biologia Celular, Embriologia e Genética, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, Santa Catarina; and 2 Departamento de Anatomia, Instituto de Ciências Biomédicas, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, 21949 - 900 Rio de Janeiro, Rio de Janeiro, Brazil

In this study, the effect of thyroid hormone (triiodothyronine, T3) on the secretion of mitogenic growth factors in astrocytes and C6 glioma cells was examined. The proliferating activity of T3 could be due, at least in part, to the astrocyte secretion of acidic and basic fibroblast growth factor (aFGF and bFGF), tumor necrosis factor-beta , and transforming growth factor-beta . In contrast, the conditioned medium (CM) of T3-treated C6 cells was mitogenic to this cell line only after hyaluronidase digestion, suggesting the impairment of growth factor mitogenic activity by hyaluronic acid. Furthermore, the presence of bFGF was significantly greater in the CM of both T3-treated astrocytes and T3-treated C6 cells than in the corresponding control CM. These data show that T3 induces cerebellar astrocytes to secrete mitogenic growth factors, predominantly bFGF, that could influence astrocyte and neuronal proliferation via autocrine and paracrine pathways.

cell proliferation; cell differentiation; fibroblast growth factors; interleukin-3


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