AJP - Endo Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 281: E1088-E1094, 2001;
0193-1849/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Trentin, A. G.
Right arrow Articles by Moura Neto, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Trentin, A. G.
Right arrow Articles by Moura Neto, V.
Vol. 281, Issue 5, E1088-E1094, November 2001

Thyroid hormone induces cerebellar astrocytes and C6 glioma cells to secrete mitogenic growth factors

A. G. Trentin1, M. Alvarez-Silva1, and V. Moura Neto2

1 Departamento de Biologia Celular, Embriologia e Genética, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, Santa Catarina; and 2 Departamento de Anatomia, Instituto de Ciências Biomédicas, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, 21949 - 900 Rio de Janeiro, Rio de Janeiro, Brazil

In this study, the effect of thyroid hormone (triiodothyronine, T3) on the secretion of mitogenic growth factors in astrocytes and C6 glioma cells was examined. The proliferating activity of T3 could be due, at least in part, to the astrocyte secretion of acidic and basic fibroblast growth factor (aFGF and bFGF), tumor necrosis factor-beta , and transforming growth factor-beta . In contrast, the conditioned medium (CM) of T3-treated C6 cells was mitogenic to this cell line only after hyaluronidase digestion, suggesting the impairment of growth factor mitogenic activity by hyaluronic acid. Furthermore, the presence of bFGF was significantly greater in the CM of both T3-treated astrocytes and T3-treated C6 cells than in the corresponding control CM. These data show that T3 induces cerebellar astrocytes to secrete mitogenic growth factors, predominantly bFGF, that could influence astrocyte and neuronal proliferation via autocrine and paracrine pathways.

cell proliferation; cell differentiation; fibroblast growth factors; interleukin-3


This article has been cited by other articles:


Home page
 Cancer Res.Home page
F. B. Davis, H.-Y. Tang, A. Shih, T. Keating, L. Lansing, A. Hercbergs, R. A. Fenstermaker, A. Mousa, S. A. Mousa, P. J. Davis, et al.
Acting via a Cell Surface Receptor, Thyroid Hormone Is a Growth Factor for Glioma Cells.
Cancer Res., July 15, 2006; 66(14): 7270 - 7275.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
A. G. Trentin
Thyroid hormone and astrocyte morphogenesis.
J. Endocrinol., May 1, 2006; 189(2): 189 - 197.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online