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Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
To examine the roles of
17
-estradiol (E2) and progesterone (Prog) in lipid
metabolism, skeletal muscle enzyme activities were studied in female
Sprague-Dawley rats. Groups included sham-operated rats (C) and
ovariectomized rats treated with placebo (O), E2 (E), Prog
(P), both hormones at physiological doses (P + E), or both hormones
with a high dose of E2 (P + HiE). Hormone (or vehicle only) delivery was via time-release pellets inserted at the time of
surgery, 15 days before metabolic testing. Results demonstrated that
carnitine palmitoyltransferase maximal activity was 19, 21, and 19%
lower (P < 0.01) in O, P, and P + E rats,
respectively, compared with C rats. Conversely, activity in E and
P + HiE rats was 14 and 19% higher (P < 0.01) than
in C. -Hydroxyacyl-CoA dehydrogenase (-HAD) maximal activity was
20% lower (P < 0.01) in O than in C rats; similarly,
P and P + E rats were 18 and 19% lower, respectively
(P < 0.01); however, treatment with E2
returned -HAD activity to C levels. These results suggest that
E2 plays a role in lipid metabolism by increasing the
maximal activity of key enzymes in the fat oxidative pathway of
skeletal muscle.
ovariectomy; estrogen; progesterone; lipid metabolism
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