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Am J Physiol Endocrinol Metab 281: E789-E793, 2001;
0193-1849/01 $5.00
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Vol. 281, Issue 4, E789-E793, October 2001

Lipid metabolism during fasting

Michael D. Jensen1, Karin Ekberg2, and Bernard R. Landau3

1 Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905; 2 Division of Clinical Physiology, Karolinska Hospital, S-171 76 Stockholm, Sweden; and 3 Departments of Medicine, Biochemistry, and Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106

These studies were conducted to understand the relationship between measures of systemic free fatty acid (FFA) reesterification and regional FFA, glycerol, and triglyceride metabolism during fasting. Indirect calorimetry was used to measure fatty acid oxidation in six men after a 60-h fast. Systemic and regional (splanchnic, renal, and leg) FFA ([3H]palmitate) and glycerol ([3H]glycerol) kinetics, as well as splanchnic triglyceride release, were measured. The rate of systemic FFA reesterification was 366 ± 93 µmol/min, which was greater (P < 0.05) than splanchnic triglyceride fatty acid output (64 ± 6 µmol/min), a measure of VLDL triglyceride fatty acid export. The majority of glycerol uptake occurred in the splanchnic and renal beds, although some leg glycerol uptake was detected. Systemic FFA release was approximately double that usually present in overnight postabsorptive men, yet the regional FFA release rates were of the same proportions previously observed in overnight postabsorptive men. In conclusion, FFA reesterification at rest during fasting far exceeds splanchnic triglyceride fatty acid output. This indicates that nonhepatic sites of FFA reesterification are important, and that peripheral reesterification of FFA exceeds the rate of simultaneous intracellular triglyceride fatty acid oxidation.

lipolysis; free fatty acids; glycerol; triglycerides


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