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1 Wisconsin Regional Primate Research Center, Madison 53715; Departments of 2 Nutritional Sciences, 3 Biostatistics and Medical Informatics, and 4 Physiology, University of Wisconsin- Madison 53706; and 5 Veterans Administration Geriatric Research, Education and Clinical Center, Madison, Wisconsin 53715; 6 Obesity Research Center, Columbia University College of Physicians and Surgeons, New York, New York 10025; and 7 Department of Physiology and Biophysics, University of Southern California, Los Angeles, California 90033
In a longitudinal study of the effects of moderate (70%) dietary restriction (DR) on aging, plasma glucose and insulin concentrations were measured from semiannual, frequently sampled intravenous glucose tolerance tests (FSIGTT) in 30 adult male rhesus monkeys. FSIGTT data were analyzed with Bergman's minimal model, and analysis of covariance revealed that restricted (R) monkeys exhibited increased insulin sensitivity (SI, P < 0.001) and plasma glucose disappearance rate (KG, P = 0.015), and reduced fasting plasma insulin (Ib, P < 0.001) and insulin response to glucose (AIRG, P = 0.023) compared with control (C; ad libitum-fed) monkeys. DR reduced the baseline fasting hyperinsulinemia of two R monkeys, whereas four C monkeys have maintained from baseline, or subsequently developed, fasting hyperinsulinemia; one has progressed to diabetes. Compared with only the normoinsulinemic C monkeys, R monkeys exhibited similarly improved FSIGTT and minimal-model parameters. Thus chronic DR not only has protected against the development of insulin resistance in aging rhesus monkeys, but has also improved glucoregulatory parameters compared with those of otherwise normoinsulinemic monkeys.
glucose metabolism; insulin; minimal model; energy restriction
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