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1 Department of Life Sciences (Sports Sciences), University of Tokyo, Tokyo 153, Japan; and Departments of 2 Kinesiology and 3 Biology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada
We examined the
postnatal changes (days 10, 36, 84, 160, 365) of
monocarboxylate transporters (MCT)1 and MCT4 in rat heart and soleus
muscle. In the heart, MCT1 protein and mRNA remained unaltered from
day 10 until 1 yr of age. Both MCT4 protein and mRNA in the
heart were detected at 10 days of age, but the MCT4 protein and
transcript were not detected thereafter. In the soleus muscle, MCT1
protein (+38%) and mRNA (+136%) increased during the first 84 days
and remained stable until 1 yr of age. In contrast, soleus MCT4 protein
decreased by 90% over the course of 1 yr, with the most rapid decrease
(
60%) occurring by day 84 (P < 0.05). At
the same time, MCT4 mRNA was increased by 74% from days 10 to 84 (P < 0.05), remaining stable
thereafter. In conclusion, developmental changes in MCT transport
proteins are tissue specific and isoform specific. Furthermore, it
appears that MCT1 expression in the heart and MCT1 and MCT4 expression
in the soleus are regulated by pretranslational processes, whereas
posttranscriptional processes regulate MCT4 expression in the soleus muscle.
monocarboxylate transporters; protein; messenger ribonucleic acid; phosphofructokinase; citrate synthase; glucose transporter 4
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