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Am J Physiol Endocrinol Metab 281: E537-E544, 2001;
0193-1849/01 $5.00
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Vol. 281, Issue 3, E537-E544, September 2001

High-altitude acclimation increases the triacylglycerol/fatty acid cycle at rest and during exercise

Grant B. McClelland1,3, Peter W. Hochachka1, Shannon P. Reidy2, and Jean-Michel Weber2

1 Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, 2 Department of Biology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5; and 3 Department of Integrative Biology, University of California, Berkeley, Berkeley, California 94720

High-altitude acclimation alters lipid metabolism during exercise, but it is unknown whether this involves changes in rates of lipolysis or reesterification, which form the triacylglycerol/fatty acid (TAG/FA) cycle. We combined indirect calorimetry with [2-3H]glycerol and [1-14C]palmitate infusions to simultaneously measure total lipid oxidation, lipolysis, and rate of appearance (Ra) of nonesterified fatty acids (NEFA) in high-altitude-acclimated (HA) rats exercising at 60% maximal O2 uptake (VO2 max). During exercise, relative total lipid oxidation (%VO2) equaled sea-level control (SL) values; however, acclimation greatly stimulated lipolysis (+75%) but had no effect on Ra NEFA. As a result, TAG/FA cycling increased (+119%), due solely to an increase in recycling (+144%) within adipocytes. There was no change in either group in these variables with the transition from rest to exercise. We conclude that, in HA, 1) acclimation is a potent stimulator of lipolysis; 2) rats do not modify TAG/FA cycling with the transition to exercise; and 3) in normoxia, HA and SL derive the same fraction of their total energy from lipids and carbohydrates.

rats; exercise intensity; lipid metabolism; lipolysis; nonesterified fatty acids; reesterification; carbohydrates; glycerol; oxidative fuel; maximal oxygen uptake


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