AJP - Endo Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 281: E524-E536, 2001;
0193-1849/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (22)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bertoldo, A.
Right arrow Articles by Cobelli, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bertoldo, A.
Right arrow Articles by Cobelli, C.
Vol. 281, Issue 3, E524-E536, September 2001

Kinetic modeling of [18F]FDG in skeletal muscle by PET: a four-compartment five-rate-constant model

A. Bertoldo1, P. Peltoniemi2,3, V. Oikonen2, J. Knuuti2, P. Nuutila2,3, and C. Cobelli1

1 Department of Electronics and Informatics, University of Padova, Padua 35131, Italy; and 2 Turku PET Centre and 3 Department of Medicine, University of Turku, F-20520 Turku, Finland

Various modeling strategies have been developed to convert regional [18F]fluorodeoxyglucose ([18F]FDG) concentration measured by positron emission tomography (PET) to a measurement of physiological parameters. However, all the proposed models have been developed and tested mostly for brain studies. The purpose of the present study is to select the most accurate model for describing [18F]FDG kinetics in human skeletal muscle. The database consists of basal and hyperinsulinemic-euglycemic studies performed in normal subjects. PET data were first analyzed by an input-output modeling technique (often called spectral analysis). These results provided guidelines for developing a compartmental model. A new model with four compartments and five rate constants (5K model) emerged as the best. By accounting for plasma and extracellular and intracellular kinetics, this model allows, for the first time, PET assessment of the individual steps of [18F]FDG kinetics in human skeletal muscle, from plasma to extracellular space to transmembrane transport into the cell to intracellular phosphorylation. Insulin is shown to affect transport and phosphorylation but not extracellular kinetics, with the transport step becoming the main site of control. The 5K model also allows definition of the domain of validity of the classic three-compartment three- or four-rate-constant models. These models are candidates for an investigative tool to quantitatively assess insulin control on individual metabolic steps in human muscle in normal and physiopathological states.

positron emission tomography; parameter estimation; glucose; compartmental model; insulin


This article has been cited by other articles:


Home page
 JNMHome page
J. P. Bankstahl, C. Kuntner, A. Abrahim, R. Karch, J. Stanek, T. Wanek, W. Wadsak, K. Kletter, M. Muller, W. Loscher, et al.
Tariquidar-Induced P-Glycoprotein Inhibition at the Rat Blood-Brain Barrier Studied with (R)-11C-Verapamil and PET
J. Nucl. Med., August 1, 2008; 49(8): 1328 - 1335.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
N. A. Mullani, R. S. Herbst, R. G. O'Neil, K. L. Gould, B. J. Barron, and J. L. Abbruzzese
Tumor Blood Flow Measured by PET Dynamic Imaging of First-Pass 18F-FDG Uptake: A Comparison with 15O-Labeled Water-Measured Blood Flow
J. Nucl. Med., April 1, 2008; 49(4): 517 - 523.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
G. Z. Ferl, X. Zhang, H.-M. Wu, and S.-C. Huang
Estimation of the 18F-FDG Input Function in Mice by Use of Dynamic Small-Animal PET and Minimal Blood Sample Data
J. Nucl. Med., December 1, 2007; 48(12): 2037 - 2045.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
A. Bertoldo, R. R. Pencek, K. Azuma, J. C. Price, C. Kelley, C. Cobelli, and D. E. Kelley
Interactions Between Delivery, Transport, and Phosphorylation of Glucose in Governing Uptake Into Human Skeletal Muscle
Diabetes, November 1, 2006; 55(11): 3028 - 3037.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. R. Pencek, A. Bertoldo, J. Price, C. Kelley, C. Cobelli, and D. E. Kelley
Dose-responsive insulin regulation of glucose transport in human skeletal muscle
Am J Physiol Endocrinol Metab, June 1, 2006; 290(6): E1124 - E1130.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
O. Langer, R. Karch, U. Muller, G. Dobrozemsky, A. Abrahim, M. Zeitlinger, E. Lackner, C. Joukhadar, R. Dudczak, K. Kletter, et al.
Combined PET and Microdialysis for In Vivo Assessment of Intracellular Drug Pharmacokinetics in Humans
J. Nucl. Med., November 1, 2005; 46(11): 1835 - 1841.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online