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Am J Physiol Endocrinol Metab 281: E248-E260, 2001;
0193-1849/01 $5.00
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Vol. 281, Issue 2, E248-E260, August 2001

Energy nutrients modulate the splanchnic sequestration of dietary nitrogen in humans: a compartmental analysis

H. Fouillet, C. Gaudichon, F. Mariotti, C. Bos, J. F. Huneau, and D. Tomé

Unité Mixte de Recherche de Physiologie de la Nutrition et du Comportement Alimentaire, Institut National de la Recherche Agronomique-Institut National Agronomique Paris-Grignon, F-75231 Paris, France

We used a previously developed compartmental model to assess the postprandial distribution and metabolism of dietary nitrogen (N) in the splanchnic and peripheral areas after the ingestion of a single meal containing milk protein either alone (MP) or with additional sucrose (SMP) or fat (FMP). The addition of fat was predicted to enhance splanchnic dietary N anabolism only transiently, without significantly affecting the global kinetics of splanchnic retention and peripheral uptake. In contrast, the addition of sucrose, which induced hyperinsulinemia, was predicted to enhance dietary N retention and anabolism in the splanchnic bed, thus leading to reduced peripheral dietary amino acid availability and anabolism. The incorporation of dietary N into splanchnic proteins was thus predicted to reach 18, 24, and 35% of ingested N 8 h after MP, FMP, and SMP, respectively. Such a model provides insight into the dynamics of the system in the nonsteady postprandial state and constitutes a useful, explanatory tool to determine the region-specific utilization of dietary N under different nutritional conditions.

protein metabolism; postprandial period; insulin; mathematical model; parameter estimation


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