AJP - Endo Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 281: E93-E99, 2001;
0193-1849/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (3)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vore, S. J.
Right arrow Articles by Butler, P. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vore, S. J.
Right arrow Articles by Butler, P. C.
Vol. 281, Issue 1, E93-E99, July 2001

Anesthesia rapidly suppresses insulin pulse mass but enhances the orderliness of insulin secretory process

Stephen J. Vore1, E. Dale Aycock1, Johannes D. Veldhuis2, and Peter C. Butler3

1 Department of Comparative Medicine, East Carolina School of Medicine, Greenville, North Carolina 27858; 2 Department of Medicine and National Science Foundation Center for Biological Timing, Charlottesville, Virginia 22908; and 3 Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California 90033

Induction of anesthesia is accompanied by modest hyperglycemia and a decreased plasma insulin concentration. Most insulin is secreted in discrete pulses occurring at ~6- to 8-min intervals. We sought to test the hypothesis that anesthesia inhibits insulin release by disrupting pulsatile insulin secretion in a canine model by use of direct portal vein sampling. We report that induction of anesthesia causes an abrupt decrease in the insulin secretion rate (1.1 ± 0.2 vs. 0.7 ± 0.1 pmol · kg-1 · min-1, P < 0.05) by suppressing insulin pulse mass (630 ± 121 vs. 270 ± 31 pmol, P < 0.01). Anesthesia also elicited an ~30% higher increase in insulin pulse frequency (P < 0.01) and more orderly insulin concentration profiles (P < 0.01). These effects were evoked by either sodium thiamylal or nitrous oxide and isoflurane. In conclusion, anesthesia represses insulin secretion through the mechanism of a twofold blunting of pulse mass despite an increase in orderly pulse frequency. These data thus unveil independent amplitude and frequency controls of beta -cells' secretory activity in vivo.

sodium thiamylal; nitrous oxide; isoflurane; pulsatile insulin


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. V. Matveyenko, J. D. Veldhuis, and P. C. Butler
Measurement of pulsatile insulin secretion in the rat: direct sampling from the hepatic portal vein
Am J Physiol Endocrinol Metab, September 1, 2008; 295(3): E569 - E574.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
A. V. Matveyenko, J. D. Veldhuis, and P. C. Butler
Mechanisms of impaired fasting glucose and glucose intolerance induced by a ~50% pancreatectomy.
Diabetes, August 1, 2006; 55(8): 2347 - 2356.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. J. Meier, J. D. Veldhuis, and P. C. Butler
Pulsatile Insulin Secretion Dictates Systemic Insulin Delivery by Regulating Hepatic Insulin Extraction In Humans
Diabetes, June 1, 2005; 54(6): 1649 - 1656.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online