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1 Endocrine Unit, and 2 Department of Dietetics, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
Exendin-4 is a long-acting potent
agonist of the glucagon-like peptide 1 (GLP-1) receptor and may be
useful in the treatment of type 2 diabetes and obesity. We examined the
effects of an intravenous infusion of exendin-4 (0.05 pmol · kg
1 · min1) compared
with a control saline infusion in healthy volunteers. Exendin-4 reduced
fasting plasma glucose levels and reduced the peak change of
postprandial glucose from baseline (exendin-4, 1.5 ± 0.3 vs.
saline, 2.2 ± 0.3 mmol/l, P < 0.05). Gastric
emptying was delayed, as measured by the paracetamol absorption method. Volunteers consumed 19% fewer calories at a free-choice buffet lunch
with exendin-4 (exendin-4, 867 ± 79 vs. saline 1,075 ± 93 kcal, P = 0.012), without reported side effects. Thus
our results are in accord with the possibility that exendin-4 may be a
potential treatment for type 2 diabetes, particularly for obese
patients, because it acts to reduce plasma glucose at least partly by a delay in gastric emptying, as well as by reducing calorie intake.
glucagon-like peptide 1; glycemia; gastric emptying; type 2 diabetes
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