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Copenhagen Muscle Research Centre, The August Krogh Institute, University of Copenhagen, DK-2100 Copenhagen, Denmark
The aim of the present
study was to examine whether ATP production increases and mechanical
efficiency decreases during intense exercise and to evaluate how
previous exercise affects ATP turnover during intense exercise. Six
subjects performed two (EX1 and EX2) 3-min one-legged knee-extensor
exercise bouts [66.2 ± 3.9 and 66.1 ± 3.9 (±SE) W]
separated by a 6-min rest period. Anaerobic ATP production, estimated
from net changes in and release of metabolites from the active muscle,
was 3.5 ± 1.2, 2.4 ± 0.6, and 1.4 ± 0.2 mmol
ATP · kg dry wt
1 · s1
during the first 5, next 10, and remaining 165 s of EX1,
respectively. The corresponding aerobic ATP production, determined from
muscle oxygen uptake, was 0.7 ± 0.1, 1.4 ± 0.2, and
4.7 ± 0.4 mmol ATP · kg dry
wt1 · s1, respectively. The mean
rate of ATP production during the first 5 s and next 10 s was
lower (P < 0.05) than during the rest of the exercise
(4.2 ± 1.2 and 3.8 ± 0.7 vs. 6.1 ± 0.3 mmol
ATP · kg dry wt1 · s1).
Thus mechanical efficiency, expressed as work per ATP produced, was
lowered (P < 0.05) in the last phase of exercise
(39.6 ± 6.1 and 40.7 ± 5.8 vs. 25.0 ± 1.3 J/mmol
ATP). The anaerobic ATP production was lower (P < 0.05) in EX2 than in EX1, but the aerobic ATP turnover was higher
(P < 0.05) in EX2 than in EX1, resulting in the same muscle ATP production in EX1 and EX2. The present data suggest that the
rate of ATP turnover increases during intense exercise at a constant
work rate. Thus mechanical efficiency declines as intense exercise is
continued. Furthermore, when intense exercise is repeated, there is a
shift toward greater aerobic energy contribution, but the total ATP
turnover is not significantly altered.
blood flow; aerobic exercise; anaerobic ATP production; lactate; creatine phosphate
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