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Am J Physiol Endocrinol Metab 280: E720-E728, 2001;
0193-1849/01 $5.00
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Vol. 280, Issue 5, E720-E728, May 2001

Insulin secretion and IP levels in two distant lineages of the genus Mus: comparisons with rat islets

Walter S. Zawalich1, Kathleen C. Zawalich1, Gregory J. Tesz1, John A. Sterpka2, and William M. Philbrick2

1 Yale University School of Nursing, and 2 Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06536

Islet responses of two different Mus geni, the laboratory mouse (Mus musculus) and a phylogenetically more ancient species (Mus caroli), were measured and compared with the responses of islets from rats (Rattus norvegicus). A minimal and flat second-phase response to 20 mM glucose was evoked from M. musculus islets, whereas a large rising second-phase response characterized rat islets. M. caroli responses were intermediate between these two extremes; a modest rising second-phase response to 20 mM glucose was observed. Prior, brief stimulation of rat islets with 20 mM glucose results in an amplified insulin secretory response to a subsequent 20 mM glucose challenge. No such potentiation or priming was observed from M. musculus islets. In contrast, M. caroli islets displayed a modest twofold potentiated first-phase response upon subsequent restimulation with 20 mM glucose. Inositol phosphate (IP) accumulation in response to 20 mM glucose stimulation in [3H]inositol-prelabeled rat or mouse islets paralleled the insulin secretory responses. The divergence in 20 mM glucose-induced insulin release between these species may be attributable to differences in phospholipase C-mediated IP accumulation in islets.

islets; insulin secretion; biphasic response; phospholipase C; evolution


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