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Am J Physiol Endocrinol Metab 280: E83-E91, 2001;
0193-1849/01 $5.00
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Vol. 280, Issue 1, E83-E91, January 2001

Effect of streptozotocin-induced diabetes on glycogen resynthesis in fasted rats post-high-intensity exercise

Luis D. M. C.-B. Ferreira1, Lambert Bräu2, Sasha Nikolovski2, Ghazala Raja2, T. Norman Palmer3, and Paul A. Fournier2

Departments of 1 Biochemistry and 2 Human Movement and Exercise Science, University of Western Australia, Perth, Western Australia 6907; and 3 Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia

It has recently been shown that food intake is not essential for the resynthesis of the stores of muscle glycogen in fasted animals recovering from high-intensity exercise. Because the effect of diabetes on this process has never been examined before, we undertook to explore this issue. To this end, groups of rats were treated with streptozotocin (60 mg/kg body mass ip) to induce mild diabetes. After 11 days, each animal was fasted for 24 h before swimming with a lead weight equivalent to 9% body mass attached to the tail. After exercise, the rate and the extent of glycogen repletion in muscles were not affected by diabetes, irrespective of muscle fiber composition. Consistent with these findings, the effect of exercise on the phosphorylation state of glycogen synthase in muscles was only minimally affected by diabetes. In contrast to its effects on nondiabetic animals, exercise in fasted diabetic rats was accompanied by a marked fall in hepatic glycogen levels, which, surprisingly, increased to preexercise levels during recovery despite the absence of food intake.

muscle; liver; recovery; rats


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