AJP - Endo Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 280: E50-E58, 2001;
0193-1849/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (29)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Højlund, K.
Right arrow Articles by Beck-Nielsen, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Højlund, K.
Right arrow Articles by Beck-Nielsen, H.
Vol. 280, Issue 1, E50-E58, January 2001

Reference intervals for glucose, beta -cell polypeptides, and counterregulatory factors during prolonged fasting

Kurt Højlund1, Mette Wildner-Christensen1, Ole Eshøj1, Christian Skjærbæk2, Jens Juul Holst3, Ole Koldkjær4, Dorte Møller Jensen1, and Henning Beck-Nielsen1

1 Diabetes Centre, Department of Endocrinology, Odense University Hospital, DK-5000 Odense C; 2 Institute of Experimental Clinical Research, Aarhus University Hospital, DK-8000 Aarhus; 3 Department of Medical Physiology, University of Copenhagen, DK-2200 Copenhagen; and 4 Department of Clinical Biochemistry, Sønderborg Hospital, DK-6400 Sønderborg, Denmark

To establish reference intervals for the pancreatic beta -cell response and the counterregulatory hormone response to prolonged fasting, we studied 33 healthy subjects (16 males, 17 females) during a 72-h fast. Glucose, insulin, C-peptide, and proinsulin levels decreased (P < 0.001), and the levels of counterregulatory factors increased during the fast [P < 0.05; glucagon and free fatty acids (FFA) with a linear increase and epinephrine, norepinephrine, and cortisol with a clear underlying circadian rhythm]. Growth hormone secretion increased from the first to third day of fasting (P < 0.05) but actually decreased from the second to third day of fasting (P = 0.03). Males had higher glucose and glucagon levels and lower FFA levels during the fast (P < 0.05), whereas no effect of gender on beta -cell polypeptides was observed. A high body mass index resulted in higher insulin and C-peptide levels during the fast (P < 0.05). In conclusion, we have provided reference intervals for glucoregulatory factors during a 72-h fast. We observed a diminished beta -cell response concomitant with an increased secretion of counterregulatory hormones. These results should be of clinical and scientific value in the investigation of hypoglycemic disorders.

catecholamines; glucagon; growth hormone; cortisol; free fatty acids


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
M. Perez-Fontan, F. Cordido, A. Rodriguez-Carmona, M. Penin, H. Diaz-Cambre, A. Lopez-Muniz, S. Sangiao-Alvarellos, and J. Garcia-Buela
Short-term regulation of peptide YY secretion by a mixed meal or peritoneal glucose-based dialysate in patients with chronic renal failure
Nephrol. Dial. Transplant., November 1, 2008; 23(11): 3696 - 3703.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
A. C Nilsson, E. M Ostman, Y. Granfeldt, and I. M. Bjorck
Effect of cereal test breakfasts differing in glycemic index and content of indigestible carbohydrates on daylong glucose tolerance in healthy subjects
Am. J. Clinical Nutrition, March 1, 2008; 87(3): 645 - 654.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
K. Hussain, J. Bryan, H. T. Christesen, K. Brusgaard, and L. Aguilar-Bryan
Serum Glucagon Counterregulatory Hormonal Response to Hypoglycemia Is Blunted in Congenital Hyperinsulinism
Diabetes, October 1, 2005; 54(10): 2946 - 2951.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. P. Girod and D. J. Brotman
Does altered glucocorticoid homeostasis increase cardiovascular risk?
Cardiovasc Res, November 1, 2004; 64(2): 217 - 226.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
K. Hojlund, T. Hansen, M. Lajer, J. E. Henriksen, K. Levin, J. Lindholm, O. Pedersen, and H. Beck-Nielsen
A Novel Syndrome of Autosomal-Dominant Hyperinsulinemic Hypoglycemia Linked to a Mutation in the Human Insulin Receptor Gene
Diabetes, June 1, 2004; 53(6): 1592 - 1598.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. Hojlund, K. J. Mustard, P. Staehr, D. G. Hardie, H. Beck-Nielsen, E. A. Richter, and J. F. P. Wojtaszewski
AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetes
Am J Physiol Endocrinol Metab, February 1, 2004; 286(2): E239 - E244.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. Ruiter, S. E. La Fleur, C. van Heijningen, J. van der Vliet, A. Kalsbeek, and R. M. Buijs
The Daily Rhythm in Plasma Glucagon Concentrations in the Rat Is Modulated by the Biological Clock and by Feeding Behavior
Diabetes, July 1, 2003; 52(7): 1709 - 1715.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
K. Hojlund, P. Staehr, B. F. Hansen, K. A. Green, D. G. Hardie, E. A. Richter, H. Beck-Nielsen, and J. F.P. Wojtaszewski
Increased Phosphorylation of Skeletal Muscle Glycogen Synthase at NH2-Terminal Sites During Physiological Hyperinsulinemia in Type 2 Diabetes
Diabetes, June 1, 2003; 52(6): 1393 - 1402.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. M. Sherck, M. Shiota, J. Saccomando, S. Cardin, E. J. Allen, J. R. Hastings, D. W. Neal, P. E. Williams, and A. D. Cherrington
Pancreatic Response to Mild Non-Insulin-Induced Hypoglycemia Does Not Involve Extrinsic Neural Input
Diabetes, November 1, 2001; 50(11): 2487 - 2496.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online