AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 280: E40-E49, 2001;
0193-1849/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (17)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johnson, J. A.
Right arrow Articles by Albu, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johnson, J. A.
Right arrow Articles by Albu, J. B.
Vol. 280, Issue 1, E40-E49, January 2001

Impaired insulin action in subcutaneous adipocytes from women with visceral obesity

Julia A. Johnson1, Susan K. Fried2, F. Xavier Pi-Sunyer1, and Jeanine B. Albu1

1 Obesity Research Center, St. Luke's-Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, New York 10025; and 2 Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey 08901

Visceral obesity is associated with resistance to the antilipolytic effect of insulin in vivo. We investigated whether subcutaneous abdominal and gluteal adipocytes from viscerally obese women exhibit insulin resistance in vitro. Subjects were obese black and white premenopausal nondiabetic women matched for visceral adipose tissue (VAT), total adiposity, and age. Independently of race and adipocyte size, increased VAT was associated with decreased sensitivity to insulin's antilipolytic effect in subcutaneous abdominal and gluteal adipocytes. Absolute lipolytic rates at physiologically relevant concentrations of insulin or the adenosine receptor agonist N6-(phenylisopropyl)adenosine were higher in subjects with the highest vs. lowest VAT area. Independently of cell size, abdominal adipocytes were less sensitive to the antilipolytic effect of insulin than gluteal adipocytes, which may partly explain increased nonesterified fatty acid fluxes in upper vs. lower body obese women. Moreover, increased VAT was associated with decreased responsiveness, but not decreased sensitivity, to insulin's stimulatory effect on glucose transport in abdominal adipocytes. These data suggest that insulin resistance of subcutaneous abdominal and, to a lesser extent, gluteal adipocytes may contribute to increased systemic lipolysis in both black and white viscerally obese women.

abdominal and gluteal adipocytes; lipolysis; glucose transport; adipose tissue


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
J. B Albu, S. Kenya, Q. He, M. Wainwright, E. S Berk, S. Heshka, D. P Kotler, and E. S Engelson
Independent associations of insulin resistance with high whole-body intermuscular and low leg subcutaneous adipose tissue distribution in obese HIV-infected women
Am. J. Clinical Nutrition, July 1, 2007; 86(1): 100 - 106.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. M. de Souza Batista, R.-Z. Yang, M.-J. Lee, N. M. Glynn, D.-Z. Yu, J. Pray, K. Ndubuizu, S. Patil, A. Schwartz, M. Kligman, et al.
Omentin Plasma Levels and Gene Expression Are Decreased in Obesity
Diabetes, June 1, 2007; 56(6): 1655 - 1661.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R.-Z. Yang, M.-J. Lee, H. Hu, J. Pray, H.-B. Wu, B. C. Hansen, A. R. Shuldiner, S. K. Fried, J. C. McLenithan, and D.-W. Gong
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action
Am J Physiol Endocrinol Metab, June 1, 2006; 290(6): E1253 - E1261.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. Li, Z. Zhu, Y. Lu, and J. G. Granneman
Metabolic and cellular plasticity in white adipose tissue II: role of peroxisome proliferator-activated receptor-{alpha}
Am J Physiol Endocrinol Metab, October 1, 2005; 289(4): E617 - E626.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. A. Johnson, J. B. Albu, E. S. Engelson, S. K. Fried, Y. Inada, G. Ionescu, and D. P. Kotler
Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy
Am J Physiol Endocrinol Metab, February 1, 2004; 286(2): E261 - E271.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
S. K Fried and S. P Rao
Sugars, hypertriglyceridemia, and cardiovascular disease
Am. J. Clinical Nutrition, October 1, 2003; 78(4): 873S - 880.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
L. E. Wagenknecht, C. D. Langefeld, A. L. Scherzinger, J. M. Norris, S. M. Haffner, M. F. Saad, and R. N. Bergman
Insulin Sensitivity, Insulin Secretion, and Abdominal Fat: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study
Diabetes, October 1, 2003; 52(10): 2490 - 2496.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. Cnop, M. J. Landchild, J. Vidal, P. J. Havel, N. G. Knowles, D. R. Carr, F. Wang, R. L. Hull, E. J. Boyko, B. M. Retzlaff, et al.
The Concurrent Accumulation of Intra-Abdominal and Subcutaneous Fat Explains the Association Between Insulin Resistance and Plasma Leptin Concentrations : Distinct Metabolic Effects of Two Fat Compartments
Diabetes, April 1, 2002; 51(4): 1005 - 1015.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online