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Am J Physiol Endocrinol Metab 280: E193-E196, 2001;
0193-1849/01 $5.00
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Vol. 280, Issue 1, E193-E196, January 2001

RAPID COMMUNICATION
Increased density of glucagon receptors in liver from endurance-trained rats

A. Légaré2, R. Drouin3, M. Milot1, D. Massicotte4, F. Péronnet3, G. Massicotte2, and C. Lavoie1

1 Département des sciences de l'activité physique and 2 Département de chimie-biologie, Université du Québec à Trois-Rivières, Trois-Rivières, Quebec G9A 5H7; 3 Département de kinésiologie, Université de Montréal, Montreal H3C 3J7; and 4 Département de kinanthropologie, Université du Québec à Montréal, Montreal, Quebec, Canada H3C 3P8

The binding properties of glucagon receptors were determined in plasma membranes isolated from liver of untrained (n = 6) and swimming endurance-trained Sprague-Dawley male rats (n = 7; 3 h/day, 5 days/wk, for 8 wk). Plasma membranes were purified from liver by aqueous two-phase affinity partitioning, and saturation kinetics were obtained by incubation of plasma membranes (10 µg of proteins/150 µl) with 125I-labeled glucagon at concentrations ranging from 0.15 to 3.0 nM for 30 min at 30°C. Saturating curve analysis indicated no difference in the affinity of glucagon receptors (0.57 ± 0.06 and 0.77 ± 0.09 nM in untrained and trained groups, respectively) but a significant higher glucagon receptor density in liver from untrained vs. trained rats (3.09 ± 0.12 vs. 4.28 ± 0.19 pmol/mg proteins). These results suggest that the reported increase in liver glucagon sensitivity in endurance-trained subjects (Drouin R, Lavoie C, Bourque J, Ducros F, Poisson D, and Chiasson J-L. Am J Physiol Endocrinol Metab 274: E23-E28, 1998) could be partly due to an increased glucagon receptor density in response to training.

upregulation; affinity; chronic exercise


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