| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Integrative Biology and Pharmacology, University of Texas - Houston Health Science Center, Houston, Texas 77030; and 2 Department of Veterinary Biomedical Sciences, University of Missouri, Columbia, Missouri 65211
ANG II mediates the hypertrophic response of overloaded cardiac muscle, likely via the ANG II type 1 (AT1) receptor. To examine the potential role of ANG II in overload-induced skeletal muscle hypertrophy, plantaris and/or soleus muscle overload was produced in female Sprague-Dawley rats (225-250 g) by the bilateral surgical ablation of either the synergistic gastrocnemius muscle (experiment 1) or both the gastrocnemius and plantaris muscles (experiment 2). In experiment 1 (n = 10/ group), inhibiting endogenous ANG II production by oral administration of an angiotensin-converting enzyme (ACE) inhibitor during a 28-day overloading protocol attenuated plantaris and soleus muscle hypertrophy by 57 and 96%, respectively (as measured by total muscle protein content). ACE inhibition had no effect on nonoverloaded (sham-operated) muscles. With the use of new animals (experiment 2; n = 8/group), locally perfusing overloaded soleus muscles with exogenous ANG II (via osmotic pump) rescued the lost hypertrophic response in ACE-inhibited animals by 71%. Furthermore, orally administering an AT1 receptor antagonist instead of an ACE inhibitor produced a 48% attenuation of overload-induced hypertrophy that could not be rescued by ANG II perfusion. Thus ANG II may be necessary for optimal overload-induced skeletal muscle hypertrophy, acting at least in part via an AT1 receptor-dependent pathway.
angiotensin-converting enzyme; angiotensin II type 1 receptor; compensatory hypertrophy; loading; mechanical stress
This article has been cited by other articles:
|
|
 |
|
  C. Yamin, O. Amir, M. Sagiv, E. Attias, Y. Meckel, N. Eynon, M. Sagiv, and R. E. Amir ACE ID genotype affects blood creatine kinase response to eccentric exercise J Appl Physiol, December 1, 2007; 103(6): 2057 - 2061. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Amir, R. Amir, C. Yamin, E. Attias, N. Eynon, M. Sagiv, M. Sagiv, and Y. Meckel Human, Environmental & Exercise: The ACE deletion allele is associated with Israeli elite endurance athletes Exp Physiol, September 1, 2007; 92(5): 881 - 886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Thomson and S. E. Gordon Impaired overload-induced muscle growth is associated with diminished translational signalling in aged rat fast-twitch skeletal muscle J. Physiol., July 1, 2006; 574(1): 291 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Westerkamp and S. E. Gordon Angiotensin-converting enzyme inhibition attenuates myonuclear addition in overloaded slow-twitch skeletal muscle Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R1223 - R1231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Kritchevsky, B. J. Nicklas, M. Visser, E. M. Simonsick, A. B. Newman, T. B. Harris, E. M. Lange, B. W. Penninx, B. H. Goodpaster, S. Satterfield, et al. Angiotensin-Converting Enzyme Insertion/Deletion Genotype, Exercise, and Physical Decline JAMA, August 10, 2005; 294(6): 691 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Y. Kostrominova, D. E. Dow, R. G. Dennis, R. A. Miller, and J. A. Faulkner Comparison of gene expression of 2-mo denervated, 2-mo stimulated-denervated, and control rat skeletal muscles Physiol Genomics, July 14, 2005; 22(2): 227 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Thomson and S. E. Gordon Diminished overload-induced hypertrophy in aged fast-twitch skeletal muscle is associated with AMPK hyperphosphorylation J Appl Physiol, February 1, 2005; 98(2): 557 - 564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S. Hopkinson, A. H. Nickol, J. Payne, E. Hawe, W. D.-C. Man, J. Moxham, H. Montgomery, and M. I. Polkey Angiotensin Converting Enzyme Genotype and Strength in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., August 15, 2004; 170(4): 395 - 399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Williams, S. S. Dhamrait, P. T. E. Wootton, S. H. Day, E. Hawe, J. R. Payne, S. G. Myerson, M. World, R. Budgett, S. E. Humphries, et al. Bradykinin receptor gene variant and human physical performance J Appl Physiol, March 1, 2004; 96(3): 938 - 942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Bahi, N. Koulmann, H. Sanchez, I. Momken, V. Veksler, A. X. Bigard, and R. Ventura-Clapier Does ACE inhibition enhance endurance performance and muscle energy metabolism in rats? J Appl Physiol, January 1, 2004; 96(1): 59 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. Childs, E. E. Spangenburg, D. R. Vyas, and F. W. Booth Temporal alterations in protein signaling cascades during recovery from muscle atrophy Am J Physiol Cell Physiol, August 1, 2003; 285(2): C391 - C398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Williams, S. H. Day, S. Dhamrait ;, and R. M. Fuentes ACE gene, physical activity, and physical fitness J Appl Physiol, October 1, 2002; 93(4): 1561 - 1562. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hlaing, X. Shen, P. Dazin, and H. S. Bernstein The Hypertrophic Response in C2C12 Myoblasts Recruits the G1 Cell Cycle Machinery J. Biol. Chem., June 21, 2002; 277(26): 23794 - 23799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. W. Smith, J. D. Smith, and D. S. Criswell Involvement of nitric oxide synthase in skeletal muscle adaptation to chronic overload J Appl Physiol, May 1, 2002; 92(5): 2005 - 2011. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
