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Am J Physiol Endocrinol Metab 280: E143-E149, 2001;
0193-1849/01 $5.00
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Vol. 280, Issue 1, E143-E149, January 2001

Muscle fatty acid oxidative capacity is a determinant of whole body fat oxidation in elderly people

Béatrice Morio1, Jean-François Hocquette3, Christophe Montaurier1, Yves Boirie1, Corinne Bouteloup-Demange1, Caroline McCormack1, Nicole Fellmann2, Bernard Beaufrère1, and Patrick Ritz1

1 Laboratoire de Nutrition Humaine, 2 Laboratoire de Physiologie et Biologie du Sport, Université d'Auvergne, Centre de Recherche en Nutrition Humaine d'Auvergne, 63009 Clermont-Ferrand; and 3 Institut National de la Recherche Agronomique, Unité de Recherches sur les Herbivores, 63122 Saint-Genès-Champanelle, France

In sedentary elderly people, a reduced muscle fatty acid oxidative capacity (MFOC) may explain a decrease in whole body fat oxidation. Eleven sedentary and seven regularly exercising subjects (65.6 ± 4.5 yr) were characterized for their aerobic fitness [maximal O2 uptake (VO2 max)/kg fat free mass (FFM)] and their habitual daily physical activity level [free-living daily energy expenditure divided by sleeping metabolic rate (DEEFLC/SMR)]. MFOC was determined by incubating homogenates of vastus lateralis muscle with [1-14C]palmitate. Whole body fat oxidation was measured by indirect calorimetry over 24 h. MFOC was 40.4 ± 14.7 and 44.3 ± 16.3 nmol palmitate · g wet tissue-1 · min-1 in the sedentary and regularly exercising individuals, respectively (P = nonsignificant). MFOC was positively correlated with DEEFLC/SMR (r = 0.58, P < 0.05) but not with VO2 max/kg FFM (r = 0.35, P = nonsignificant). MFOC was the main determinant of fat oxidation during all time periods including physical activity. Indeed, MFOC explained 19.7 and 30.5% of the variance in fat oxidation during walking and during the alert period, respectively (P < 0.05). Furthermore, MFOC explained 23.0% of the variance in fat oxidation over 24 h (P < 0.05). It was concluded that, in elderly people, MFOC may be influenced more by overall daily physical activity than by regular exercising. MFOC is a major determinant of whole body fat oxidation during physical activities and, consequently, over 24 h.

habitual physical activity; endurance training; indirect calorimetry; vastus lateralis muscle


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