AJP - Endo AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 280: E130-E142, 2001;
0193-1849/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (30)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yaspelkis, B. B.
Right arrow Articles by Levin, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yaspelkis, B. B., III
Right arrow Articles by Levin, N.
Vol. 280, Issue 1, E130-E142, January 2001

Leptin administration improves skeletal muscle insulin responsiveness in diet-induced insulin-resistant rats

Ben B. Yaspelkis III1, James R. Davis2, Maziyar Saberi1, Toby L. Smith1, Reza Jazayeri1, Mohenish Singh1, Victoria Fernandez1, Beatriz Trevino1, Narumol Chinookoswong3, Jinlin Wang3, Zhi Qing Shi3, and Nancy Levin2

1 Exercise Biochemistry Laboratory, Department of Kinesiology, California State University Northridge, Northridge 91330-8287; and Departments of 2 Neuroscience and 3 Pharmacology, Amgen Incorporated, Thousand Oaks, California 91320-1799

In addition to suppressing appetite, leptin may also modulate insulin secretion and action. Leptin was administered here to insulin-resistant rats to determine its effects on secretagogue-stimulated insulin release, whole body glucose disposal, and insulin-stimulated skeletal muscle glucose uptake and transport. Male Wistar rats were fed either a normal (Con) or a high-fat (HF) diet for 3 or 6 mo. HF rats were then treated with either vehicle (HF), leptin (HF-Lep, 10 mg · kg-1 · day-1 sc), or food restriction (HF-FR) for 12-15 days. Glucose tolerance and skeletal muscle glucose uptake and transport were significantly impaired in HF compared with Con. Whole body glucose tolerance and rates of insulin-stimulated skeletal muscle glucose uptake and transport in HF-Lep were similar to those of Con and greater than those of HF and HF-FR. The insulin secretory response to either glucose or tolbutamide (a pancreatic beta -cell secretagogue) was not significantly diminished in HF-Lep. Total and plasma membrane skeletal muscle GLUT-4 protein concentrations were similar in Con and HF-Lep and greater than those in HF and HF-FR. The findings suggest that chronic leptin administration reversed a high-fat diet-induced insulin-resistant state, without compromising insulin secretion.

ob gene product; high-fat diet; glucose tolerance; glucose uptake and transport; GLUT-4 protein


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. B. Yaspelkis III, S. J. Lessard, D. W. Reeder, J. J. Limon, M. Saito, D. A. Rivas, I. Kvasha, and J. A. Hawley
Exercise reverses high-fat diet-induced impairments on compartmentalization and activation of components of the insulin-signaling cascade in skeletal muscle
Am J Physiol Endocrinol Metab, October 1, 2007; 293(4): E941 - E949.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. J. Dube, B. A. Bhatt, N. Dedousis, A. Bonen, and R. M. O'Doherty
Leptin, skeletal muscle lipids, and lipid-induced insulin resistance
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R642 - R650.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
H. J. Herr, J. R. Bernard, D. W. Reeder, D. A. Rivas, J. J. Limon, and B. B. Yaspelkis III
Insulin-stimulated plasma membrane association and activation of Akt2, aPKC {zeta} and aPKC {lambda} in high fat fed rodent skeletal muscle
J. Physiol., June 1, 2005; 565(2): 627 - 636.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. D. Krisan, D. E. Collins, A. M. Crain, C. C. Kwong, M. K. Singh, J. R. Bernard, and B. B. Yaspelkis III
Resistance training enhances components of the insulin signaling cascade in normal and high-fat-fed rodent skeletal muscle
J Appl Physiol, May 1, 2004; 96(5): 1691 - 1700.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. R. Steinberg, M. L. Parolin, G. J. F. Heigenhauser, and D. J. Dyck
Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance
Am J Physiol Endocrinol Metab, July 1, 2002; 283(1): E187 - E192.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. R. Steinberg, D. J. Dyck, J. Calles-Escandon, N. N. Tandon, J. J. F. P. Luiken, J. F. C. Glatz, and A. Bonen
Chronic Leptin Administration Decreases Fatty Acid Uptake and Fatty Acid Transporters in Rat Skeletal Muscle
J. Biol. Chem., March 8, 2002; 277(11): 8854 - 8860.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. R. Steinberg, A. Bonen, and D. J. Dyck
Fatty acid oxidation and triacylglycerol hydrolysis are enhanced after chronic leptin treatment in rats
Am J Physiol Endocrinol Metab, March 1, 2002; 282(3): E593 - E600.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online