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Am J Physiol Endocrinol Metab 280: E120-E129, 2001;
0193-1849/01 $5.00
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Vol. 280, Issue 1, E120-E129, January 2001

Effects of hyperprolactinemia on rat prostate growth: evidence of androgeno-dependence

Fabien Van Coppenolle1,*, Christian Slomianny1,*, Françoise Carpentier2, Xuefen Le Bourhis3, Ahmed Ahidouch1, Dominique Croix4, Guillaume Legrand1, Etienne Dewailly1, Sarah Fournier1, Henri Cousse5, Dominique Authie6, Jean-Pierre Raynaud7, Jean-Claude Beauvillain4, Jean-Paul Dupouy8, and Natalia Prevarskaya1

1 Laboratoire de Physiologie Cellulaire, Institut National de la Santé et de la Recherche Médicale (INSERM) EPI-9938, 3 Laboratoire de Biologie du Développement, and 8 Laboratoire de Neuroendocrinologie du Développement, Université des Sciences et Technologies de Lille, 59655 Villeneuve d'Ascq; 2 Service d'Anatomo-pathologie, Centre Hospitalier de Roubaix, 59056 Roubaix; 4 Laboratoire de Neuroendocrinologie et de Physiopathologie neuronale, INSERM U422, 59045 Lille; 5 Laboratoire Pierre Fabre, La Chartreuse, and 6 Laboratoire Pierre Fabre Médicaments, 81106 Castres; and 7 Université Pierre et Marie Curie, 75006 Paris, France

The effects of the polypeptide hormone prolactin (PRL) in the development and regulation of benign prostate hyperplasia (BPH) and also in prostate cancer are not very well characterized. This study examines the action of PRL, either alone or in association with androgens [testosterone (T) or dihydrotestosterone (DHT)], in the rat prostate gland. The effects of PRL and androgens were investigated after 30 and 60 days in control, castrated, castrated with a substitutive implant of T or DHT, and sham-operated Wistar rats. To enhance PRL release, we induced hyperprolactinemia by administering chronic injections of sulpiride (40 mg · kg-1 · day-1). Chronic hyperprolactinemia induces enlargement and inflammation of the lateral rat prostate without any histological changes on ventral and dorsal lobes. We also demonstrate that hyperprolactinemia induces Bcl-2 overexpression in the lateral rat prostate and that this could inhibit the level of apoptosis. The in vivo model established here is a useful in vivo approach for studying the hormonal regulation of normal and pathological prostate development.

prolactin; testosterone; dihydrotestosterone

* These authors contributed equally to this work.




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