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Am J Physiol Endocrinol Metab 279: E1294-E1304, 2000;
0193-1849/00 $5.00
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Vol. 279, Issue 6, E1294-E1304, December 2000

Effect of hyperinsulinemia on amino acid utilization in the ovine fetus

Patti J. Thureen1, Bryan Scheer3, Susan M. Anderson1, Janet A. Tooze2, David A. Young2, and William W. Hay Jr.1

1 Perinatal Research Center and Departments of Pediatrics and 2 Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, 80262; and 3 Department of Surgery, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma, 73190

We studied the effect of an acute 4-h period of hyperinsulinemia (H) on net utilization rates (AAURnet) of 21 amino acids (AA) in 17 studies performed in 13 late-gestation fetal sheep by use of a novel fetal hyperinsulinemic-euglycemic-euaminoacidemic clamp. During H [84 ± 12 (SE) µU/ml H, 15 ± 2 µU/ml control (C), P < 0.00001], euglycemia was maintained by glucose clamp (19 ± 0.05 µmol/ml H, 1.19 ± 0.04 µmol/ml C), and euaminoacidemia (mean 4.1 ± 3.3% increase for all amino acid concentrations [AA], nonsignificantly different from zero) was maintained with a mixed amino acid solution adjusted to keep lysine concentration constant and other [AA] near C values. H produced a 63.7% increase in AAURnet (3.29 ± 0.66 µmol · min-1 · kg-1 H, 2.01 ± 0.55 µmol · min-1 · kg-1 C, P < 0.001), accounting for a 60.1% increase in fetal nitrogen uptake rate (2,064 ± 108 mg · day-1 · kg-1 H, 1,289 ± 73 mg · day-1 · kg-1 C, P < 0.001). Mean AA clearance rate (AAURnet/[AA]) increased by 64.5 ± 18.9% (P < 0.001). Thus acute physiological H increases net amino acid and nitrogen utilization rates in the ovine fetus independent of plasma glucose and [AA].

glucose; insulin; amino acids; sheep; nitrogen


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