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Am J Physiol Endocrinol Metab 279: E1264-E1270, 2000;
0193-1849/00 $5.00
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Vol. 279, Issue 6, E1264-E1270, December 2000

Evidence for physiological coupling of insulin-mediated glucose metabolism and limb blood flow

Kieren Mather1, Markku Laakso2, Steven Edelman3, Ginger Hook1, and Alain Baron1

1 Division of Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana 46202; 2 Department of Medicine, Kuopio University Hospital, Kuopio, Finland 70210; and 3 Division of Endocrinology, Department of Medicine, University of California San Diego Veterans Affairs Medical Center, San Diego, California 92161

We hypothesized that the vasodilation observed during insulin stimulation is closely coupled to the rate of glucose metabolism. Lean (L, n = 13), obese nondiabetic (OB, n = 13), and obese type 2 diabetic subjects (Type 2 DM, n = 16) were studied. Leg blood flow (LBF) was examined under conditions of euglycemic hyperinsulinemia (EH) and hyperglycemic hyperinsulinemia (HH), which produced a steady-state whole body glucose disposal rate (GDR) of ~2,000 µmol · m-2 · min-1. At this GDR, under both conditions, subjects across the range of insulin sensitivity exhibited equivalent LBF (l/min EH: L, 0.42 ± 0.03; OB, 0.43 ± 0.03; Type 2 DM, 0.38 ± 0.07; P = 0.72 by ANOVA. HH: L, 0.44 ± 0.04; OB, 0.39 ± 0.05; Type 2 DM, 0.41 ± 0.04; P = 0.71). The continuous relationship between LBF and GDR did not differ across subject groups [slope × 10-5 l/(µmol · m-2 · min-1) by ANOVA. EH: L, 8.6; OB, 9.2; Type 2 DM, 7.9; P = 0.91. HH: L, 4.2; OB, 2.5; Type 2 DM, 4.1; P = 0.77], although this relationship did differ between the EH and HH conditions (P = 0.001). These findings support a physiological coupling of LBF and insulin-mediated glucose metabolism. The mechanism(s) linking substrate delivery and metabolism appears to be intact in insulin-resistant states.




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