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Am J Physiol Endocrinol Metab 279: E1139-E1144, 2000;
0193-1849/00 $5.00
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Vol. 279, Issue 5, E1139-E1144, November 2000

Age-induced changes in pancreatic islet blood flow: evidence for an impaired regulation in diabetic GK rats

Annika M. Svensson1, Claes-Göran Östenson2, and Leif Jansson1

1 Department of Medical Cell Biology, Uppsala University, SE-751 23 Uppsala; and 2 The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institute and Hospital, SE-17176 Stockholm, Sweden

The present study aimed to compare longitudinal variations in islet blood perfusion in rats with different degrees of impairment of glucose metabolism. For this purpose, mildly diabetic Goto-Kakizaki (GK) rats, glucose intolerant F1 hybrids of GK and Wistar (W) rats (H), and control W rats were examined at 5 wk, 12 wk, or 1 yr of age, using the microsphere technique for blood flow measurements. W rats showed progressively increasing islet blood flow (IBF) throughout the experiment. Both GK and H rats demonstrated increasing IBF between 5 and 12 wk. However, H rats showed no further increment in IBF at 1 yr, whereas GK rats displayed a pronounced decrease in IBF between 12 wk and 1 yr of age. The augmented IBF seen in older W rats may constitute an adaptation to the increasing demand for insulin secretion in aging rats. The inability to adapt to the increased demand for insulin secretion by upregulation of islet blood flow could contribute to the progressive deterioration of glucose metabolism seen in the aging GK rat.

type 2 diabetes; aging


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