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Am J Physiol Endocrinol Metab 279: E1072-E1079, 2000;
0193-1849/00 $5.00
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Vol. 279, Issue 5, E1072-E1079, November 2000

Fatty acid transport protein-1 mRNA expression in skeletal muscle and in adipose tissue in humans

Christophe Binnert1,*, Heikki A. Koistinen2,*, Geneviève Martin3, Fabrizio Andreelli1, Pertti Ebeling2, Veikko A. Koivisto2, Martine Laville1, Johan Auwerx3, and Hubert Vidal1

1 Institut National de la Santé et de la Recherche Médicale Unité-449 and Centre de Recherche en Nutrition Humaine de Lyon, Faculté de Médecine R.T.H. Laënnec, F-69372 Lyon; 3 Institut de Génétique et Biologie Moléculaire et Cellulaire, 67404 Illkirch, France; and 2 Department of Medicine, Division of Geriatrics, Helsinki University Central Hospital, 00290 Helsinki, Finland

Fatty acid transporter protein (FATP)-1 mRNA expression was investigated in skeletal muscle and in subcutaneous abdominal adipose tissue of 17 healthy lean, 13 nondiabetic obese, and 16 obese type 2 diabetic subjects. In muscle, FATP-1 mRNA levels were higher in lean women than in lean men (2.2 ± 0.1 vs. 0.6 ± 0.2 amol/µg total RNA, P < 0.01). FATP-1 mRNA expression was decreased in skeletal muscle in obese women both in nondiabetic and in type 2 diabetic patients (P < 0.02 vs. lean women in both groups), and in all women there was a negative correlation with basal FATP-1 mRNA level and body mass index (r = -0.74, P < 0.02). In men, FATP-1 mRNA was expressed at similar levels in the three groups both in skeletal muscle (0.6 ± 0.2, 0.6 ± 0.2, and 0.8 ± 0.2 amol/µg total RNA in lean, obese, and type 2 diabetic male subjects) and in adipose tissue (0.9 ± 0.2 amol/µg total RNA in the 3 groups). Insulin infusion (3 h) reduced FATP-1 mRNA levels in muscle in lean women but not in lean men. Insulin did not affect FATP-1 mRNA expression in skeletal muscle in obese nondiabetic or in type 2 diabetic subjects nor in subcutaneous adipose tissue in any of the three groups. These data show a gender-related difference in the expression of the fatty acid transporter FATP-1 in skeletal muscle of lean individuals and suggest that changes in FATP-1 expression may not contribute to a large extent to the alterations in fatty acid uptake in obesity and/or type 2 diabetes.

fatty acids; insulin; insulin resistance; obesity; type 2 diabetes mellitus; hyperinsulinemic clamp; reverse transcription-polymerase chain reaction; messenger ribonucleic acid

* C. Binnert and H. A. Koistinen contributed equally to this work.




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