AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 279: E630-E637, 2000;
0193-1849/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (31)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mittelman, S. D.
Right arrow Articles by Bergman, R. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mittelman, S. D.
Right arrow Articles by Bergman, R. N.
Vol. 279, Issue 3, E630-E637, September 2000

Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin

Steven D. Mittelman and Richard N. Bergman

Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9142

We have shown that insulin controls endogenous glucose production (EGP) indirectly, via suppression of adipocyte lipolysis. Free fatty acids (FFA) and EGP are suppressed proportionately, and when the decline in FFA is prevented during insulin infusion, suppression of EGP is also prevented. The present study tested the hypothesis that suppression of lipolysis under conditions of constant insulin would yield a suppression of EGP. N6-cyclohexyladenosine (CHA) was used to selectively suppress adipocyte lipolysis during euglycemic clamps in conscious male dogs. FFA suppression by CHA caused suppression of EGP. Liposyn control experiments, which maintained FFA levels above basal during CHA infusion, completely prevented the decline in EGP, whereas glycerol control experiments, which maintained glycerol levels close to basal, did not prevent a decline in EGP. These controls suggest that the EGP suppression was secondary to the suppression of FFA levels specifically. A difference in the sensitivity of FFA and EGP suppression (FFA were suppressed ~85% whereas EGP only declined ~40%) was possibly caused by confounding effects of CHA, including an increase in catecholamine and glucagons levels during CHA infusion. Thus suppression of lipolysis under constant insulin causes suppression of EGP, despite a significant rise in catecholamines.

free fatty acids; hepatic glucose output; catecholamines; adenosine


This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
O. Johnston, C. L. Rose, A. C. Webster, and J. S. Gill
Sirolimus Is Associated with New-Onset Diabetes in Kidney Transplant Recipients
J. Am. Soc. Nephrol., July 1, 2008; 19(7): 1411 - 1418.
[Full Text] [PDF]

Home page
 CJASNHome page
M. F. Crutchlow and R. D. Bloom
Transplant-Associated Hyperglycemia: A New Look at an Old Problem
Clin. J. Am. Soc. Nephrol., March 1, 2007; 2(2): 343 - 355.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. M. Rumberger, T. Peters Jr, C. Burrington, and A. Green
Transferrin and Iron Contribute to the Lipolytic Effect of Serum in Isolated Adipocytes
Diabetes, October 1, 2004; 53(10): 2535 - 2541.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
H. van Thien, G. J. Weverling, M. T. Ackermans, N. canh Hung, E. Endert, P. A. Kager, and H. P. Sauerwein
FFAs are not involved in regulation of gluconeogenesis and glycogenolysis in adults with uncomplicated P. falciparum malaria
Am J Physiol Endocrinol Metab, October 1, 2004; 287(4): E609 - E615.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. N. Clore, J. S. Stillman, J. Li, S. J. D. O'Keefe, and J. R. Levy
Differential effect of saturated and polyunsaturated fatty acids on hepatic glucose metabolism in humans
Am J Physiol Endocrinol Metab, August 1, 2004; 287(2): E358 - E365.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. Basu, W. F. Schwenk, and R. A. Rizza
Both fasting glucose production and disappearance are abnormal in people with "mild" and "severe" type 2 diabetes
Am J Physiol Endocrinol Metab, July 1, 2004; 287(1): E55 - E62.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
P. Staehr, O. Hother-Nielsen, B. R. Landau, V. Chandramouli, J. J. Holst, and H. Beck-Nielsen
Effects of Free Fatty Acids Per Se on Glucose Production, Gluconeogenesis, and Glycogenolysis
Diabetes, February 1, 2003; 52(2): 260 - 267.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
M. L. Cruz, R. N. Bergman, and M. I. Goran
Unique Effect of Visceral Fat on Insulin Sensitivity in Obese Hispanic Children With a Family History of Type 2 Diabetes
Diabetes Care, September 1, 2002; 25(9): 1631 - 1636.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. Mittendorfer, J. F. Horowitz, and S. Klein
Gender differences in lipid and glucose kinetics during short-term fasting
Am J Physiol Endocrinol Metab, December 1, 2001; 281(6): E1333 - E1339.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
R. Lattermann, T. Schricker, U. Wachter, M. Georgieff, and A. Goertz
Understanding the Mechanisms by Which Isoflurane Modifies the Hyperglycemic Response to Surgery
Anesth. Analg., July 1, 2001; 93(1): 121 - 127.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online