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Am J Physiol Endocrinol Metab 279: E293-E300, 2000;
0193-1849/00 $5.00
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Vol. 279, Issue 2, E293-E300, August 2000

Effect of high-fat diet, surrounding temperature, and enterostatin on uncoupling protein gene expression

Catarina Rippe1, Karin Berger1, Charlotta Böiers1, Daniel Ricquier2, and Charlotte Erlanson-Albertsson1

1 Section for Molecular Signaling, Department of Cell and Molecular Biology, University of Lund, S-221 00 Lund, Sweden; and 2 Centre National de la Recherche Scientifique, 92190 Meudon, France

Nonshivering thermogenesis induced in brown adipose tissue (BAT) during high-fat feeding is mediated through uncoupling protein 1 (UCP1). UCP2 is a recently identified homologue found in many tissues. To determine the role of UCP1 and UCP2 in thermoregulation and energy balance, we investigated the long-term effect of high-fat feeding on mRNA levels in mice at two different ambient temperatures. We also treated mice with the anorectic peptide enterostatin and compared mRNA levels in BAT, white adipose tissue (WAT), stomach, and duodenum. Here, we report that high-fat feeding at 23°C increased UCP1 and UCP2 levels in BAT four- and threefold, respectively, and increased UCP2 levels fourfold in WAT. However, at 29°C, UCP1 decreased, whereas UCP2 remained unchanged in BAT and increased twofold in WAT. Enterostatin increased UCP1 and decreased UCP2 mRNA in BAT. In stomach and duodenum, high-fat feeding decreased UCP2 mRNA, whereas enterostatin increased it. Our results suggest that the regulation of uncoupling protein mRNA levels by high-fat feeding is dependent on ambient temperature and that enterostatin is able to modulate it.

uncoupling protein 1; uncoupling protein 2; colipase; thermogenesis; thermoneutrality


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