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1 Department of Molecular Physiology and Biophysics, 2 Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
The aim of this study was to
determine whether the elimination of the hepatic arterial-portal (A-P)
venous glucose gradient would alter the effects of portal glucose
delivery on hepatic or peripheral glucose uptake. Three groups of
42-h-fasted conscious dogs (n = 7/group) were studied.
After a 40-min basal period, somatostatin was infused peripherally
along with intraportal insulin (7.2 pmol·kg
1·min1) and glucagon (0.65 ng·kg1·min1). In test
period 1 (90 min), glucose was infused into a peripheral vein to
double the hepatic glucose load (HGL) in all groups. In test
period 2 (90 min) of the control group (CONT), saline was infused
intraportally; in the other two groups, glucose was infused intraportally (22.2 µmol·kg1·min1). In the
second group (PD), saline was simultaneously infused into the
hepatic artery; in the third group (PD+HAD), glucose was infused into
the hepatic artery to eliminate the negative hepatic A-P glucose
gradient. HGL was twofold basal in each test period. Net hepatic
glucose uptake (NHGU) was 10.1 ± 2.2 and 12.8 ± 2.1 vs.
11.5 ± 1.6 and 23.8 ± 3.3* vs. 9.0 ± 2.4 and
13.8 ± 4.2 µmol · kg1·min1 in the two periods of CONT,
PD, and PD+HAD, respectively (* P < 0.05 vs. same
test period in PD and PD+HAD). NHGU was 28.9 ± 1.2 and 39.5 ± 4.3 vs. 26.3 ± 3.7 and 24.5 ± 3.7* vs. 36.1 ± 3.8 and 53.3 ± 8.5 µmol·kg1·min1 in the first
and second periods of CONT, PD, and PD+HAD, respectively (* P < 0.05 vs. same test period in PD and PD+HAD).
Thus the increment in NHGU and decrement in extrahepatic glucose uptake
caused by the portal signal were significantly reduced by hepatic
arterial glucose infusion. These results suggest that the hepatic
arterial glucose level plays an important role in generation of the
effect of portal glucose delivery on glucose uptake by liver and muscle.
liver; liver nerve; hepatic glucose uptake
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