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1 Department of Medicine, Obesity Research Center, St. Luke's-Roosevelt Hospital, Columbia University, New York, New York 10025; and 2 Departments of Medicine and Chemistry, University of Vermont, Burlington, Vermont 05405
We sought to determine if
decrements in the mass of fat-free body mass (FFM) and other lean
tissue compartments, and related changes in protein metabolism, are
appropriate for weight loss in obese older women. Subjects were 14 healthy weight-stable obese (BMI 
30 kg/m2) postmenopausal
women >55 yr who participated in a 16-wk, 1,200 kcal/day nutritionally
complete diet. Measures at baseline and 16 wk included FFM and
appendicular lean soft tissue (LST) by dual-energy X-ray
absorptiometry; body cell mass (BCM) by 40K whole body
counting; total body water (TBW) by tritium dilution; skeletal muscle
(SM) by whole body MRI; and fasting whole body protein metabolism
through L-[1-13C]leucine kinetics. Mean
weight loss (±SD) was 9.6 ± 3.0 kg (P < 0.0001)
or 10.7% of initial body weight. FFM decreased by 2.1 ± 2.6 kg
(P = 0.006), or 19.5% of weight loss, and did not
differ from that reported (2.3 ± 0.7 kg). Relative losses of SM,
LST, TBW, and BCM were consistent with reductions in body weight and FFM. Changes in [13C]leucine flux, oxidation, and
synthesis rates were not significant. Follow-up of 11 subjects at
23.7 ± 5.7 mo showed body weight and fat mass to be below
baseline values; FFM was nonsignificantly reduced. Weight loss was
accompanied by body composition and protein kinetic changes that appear
appropriate for the magnitude of body mass change, thus failing to
support the concern that diet-induced weight loss in obese
postmenopausal women produces disproportionate LST losses.
obesity treatment; skeletal muscle mass
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