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Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110
We measured whole body and regional lipolytic and adipose
tissue blood flow (ATBF) sensitivity to epinephrine in 8 lean
[body mass index (BMI): 21 ± 1 kg/m2] and 10 upper body obese (UBO) women (BMI: 38 ± 1 kg/m2; waist
circumference >100 cm). All subjects underwent a four-stage epinephrine infusion (0.00125, 0.005, 0.0125, and 0.025 µg · kg fat-free
mass
1 · min1)
plus pancreatic hormonal clamp. Whole body free fatty acid (FFA) and
glycerol rates of appearance (Ra) in plasma were determined by stable isotope tracer methodology. Abdominal and femoral
subcutaneous adipose tissue lipolytic activity was determined by
microdialysis and 133Xe clearance methods. Basal whole body
FFA Ra and glycerol Ra were both greater
(P < 0.05) in obese (449 ± 31 and 220 ± 12 µmol/min, respectively) compared with lean subjects (323 ± 44 and 167 ± 21 µmol/min, respectively). Epinephrine infusion significantly increased
FFA Ra and glycerol Ra in lean (71 ± 21 and
122 ± 52%, respectively; P < 0.05) but not obese subjects
(7 ± 6 and 39 ± 10%, respectively; P = not significant).
In addition, lipolytic and ATBF sensitivity to epinephrine was blunted
in abdominal but not femoral subcutaneous adipose tissue of obese
compared with lean subjects. We conclude that whole body lipolytic
sensitivity to epinephrine is blunted in women with UBO because of
decreased sensitivity in upper body but not lower body subcutaneous
adipose tissue.
lipolysis; catecholamine; adipose tissue blood flow; stable isotopes; pancreatic clamp
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