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Am J Physiol Endocrinol Metab 278: E1027-E1030, 2000;
0193-1849/00 $5.00
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Vol. 278, Issue 6, E1027-E1030, June 2000

Role of adrenal renin-angiotensin system in the control of aldosterone secretion in sodium-restricted rats

Giuseppina Mazzocchi1, Ludwik K. Malendowicz2, Anna Markowska2, Giovanna Albertin1, and Gastone G. Nussdorfer1

1 Section of Anatomy, Department of Human Anatomy and Physiology, University of Padua, I-35121 Padua, Italy; and 2 Department of Histology and Embryology, School of Medicine, PL-60781 Poznan, Poland

This study examined the effect of the pharmacological manipulation of adrenal renin-angiotensin system (RAS) on aldosterone secretion from in situ perfused adrenals of rats kept on a normal diet and sodium restricted for 14 days. Neither the angiotensin-converting enzyme inhibitor captopril nor the nonselective angiotensin II receptor antagonist saralasin and the AT1 receptor-selective antagonist losartan affected basal aldosterone output in normally fed rats. In contrast, they concentration dependently decreased aldosterone secretion in sodium-restricted animals, with maximal effective concentration ranging from 10-7 to 10-6 M. Captopril (10-6 M), saralasin (10-6 M), and losartan (10-7 M) counteracted aldosterone response to 10 mM K+ in sodium-restricted rats but not in normally fed animals. Collectively, these findings provide evidence that adrenal RAS plays a role in the regulation of aldosterone secretion, but only under conditions of prolonged stimulation of zona glomerulosa probably leading to overexpression of adrenal RAS.

in situ adrenal perfusion


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