AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 278: E716-E728, 2000;
0193-1849/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (48)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Aussedat, B.
Right arrow Articles by Reach, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Aussedat, B.
Right arrow Articles by Reach, G.
Vol. 278, Issue 4, E716-E728, April 2000

Interstitial glucose concentration and glycemia: implications for continuous subcutaneous glucose monitoring

B. Aussedat1, M. Dupire-Angel1, R. Gifford2, J. C. Klein3, G. S. Wilson4, and G. Reach1

1 Department of Diabetology, Institut National de la Santé et de la Recherche Médicale U341, Hôtel-Dieu, 75004 Paris, France; 2 National Applied Science, Portland, Oregon 97224; 3 Centre de Morphologie Mathématique, Ecole des Mines, 77305 Fontainebleau, France; and 4 Department of Chemistry, University of Kansas, Lawrence, Kansas 66045

The changes in plasma glucose concentration and in interstitial glucose concentration, determined with a miniaturized subcutaneous glucose sensor, were investigated in anesthetized nondiabetic rats. Interstitial glucose was estimated through two different calibration procedures. First, after a glucose load, the magnitude of the increase in interstitial glucose, estimated through a one-point calibration procedure, was 70% of that in plasma glucose. We propose that this is due to the effect of endogenous insulin on peripheral glucose uptake. Second, during the spontaneous secondary decrease in plasma glucose after the glucose load, interstitial glucose decreased faster than plasma glucose, which may also be due to the effect of insulin on peripheral glucose uptake. Third, during insulin-induced hypoglycemia, the decrease in interstitial glucose was less marked than that of plasma glucose, suggesting that hypoglycemia suppressed transfer of glucose into the interstitial tissue; subsequently, interstitial glucose remained lower than plasma glucose during its return to basal value, suggesting that the stimulatory effect of insulin on peripheral glucose uptake was protracted. If these observations obtained in rats are relevant to human physiology, such discrepancies between plasma and interstitial glucose concentration may have major implications for the use of a subcutaneous glucose sensor in continuous blood glucose monitoring in diabetic patients.

glucose sensor; insulin; phlorizin; subcutaneous tissue


This article has been cited by other articles:


Home page
 Diabetes CareHome page
P. G. McNally, J. D. Dean, A. D. Morris, P. D. Wilkinson, G. Compion, and S. R. Heller
Using Continuous Glucose Monitoring to Measure the Frequency of Low Glucose Values When Using Biphasic Insulin Aspart 30 Compared With Biphasic Human Insulin 30: A double-blind crossover study in individuals with type 2 diabetes
Diabetes Care, May 1, 2007; 30(5): 1044 - 1048.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. Sieg, R. H. Guy, and M. B. Delgado-Charro
Noninvasive Glucose Monitoring by Reverse Iontophoresis in Vivo: Application of the Internal Standard Concept
Clin. Chem., August 1, 2004; 50(8): 1383 - 1390.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
E. Kulcu, J. A. Tamada, G. Reach, R. O. Potts, and M. J. Lesho
Physiological Differences Between Interstitial Glucose and Blood Glucose Measured in Human Subjects
Diabetes Care, August 1, 2003; 26(8): 2405 - 2409.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
B. Guerci, M. Floriot, P. Bohme, D. Durain, M. Benichou, S. Jellimann, and P. Drouin
Clinical Performance of CGMS in Type 1 Diabetic Patients Treated by Continuous Subcutaneous Insulin Infusion Using Insulin Analogs
Diabetes Care, March 1, 2003; 26(3): 582 - 589.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
E. Pekkala, L. Valikangas, M. Puukka, L. Tjaderhane, and M. Larmas
The Effect of a High-sucrose Diet on Dentin Formation and Dental Caries in Hyperinsulinemic Rats
J. Dent. Res., August 1, 2002; 81(8): 536 - 540.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
A. Maran, C. Crepaldi, A. Tiengo, G. Grassi, E. Vitali, G. Pagano, S. Bistoni, G. Calabrese, F. Santeusanio, F. Leonetti, et al.
Continuous Subcutaneous Glucose Monitoring in Diabetic Patients: A multicenter analysis
Diabetes Care, February 1, 2002; 25(2): 347 - 352.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
W. K. Ward
Subcutaneous Glucose Monitoring: Microdialysis vs. intracorporeal
Diabetes Care, February 1, 2002; 25(2): 410 - 410.
[Full Text]

Home page
 Diabetes CareHome page
G. Reach
Which Threshold to Detect Hypoglycemia?: Value of receiver-operator curve analysis to find a compromise between sensitivity and specificity
Diabetes Care, May 1, 2001; 24(5): 803 - 804.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online